Root Cause of Mood Issues – Podcast #229

Root Cause of Mood Issues – Podcast #229


Dr. Justin Marchegiani: Hey there it’s Dr.
Justin Marchegiani. Welcome back to the podcast. We have Evan Brand here. Today we’re gonna
do a live podcast today on mood and natural mood solutions, getting to the root cause
of your mood concerns. So we’re live on Facebook here as well live on YouTube. Make sure you
click down below, leave us some comments, we want to know what you think we appreciate
a share we appreciate the like. Obviously subscribe and don’t forget to smash the bell
so you can get notifications of our awesome content coming up. So, Evan how are we doing
today man? Evan Brand: Hey man I’m doing pretty good.
I’m looking for statistics right now to make sure we can discuss how many people have depression
how many people have anxiety. The Center for Disease Control they study this stuff and
so I want to make sure people understand this, its not just Dr. Justin Marchegiani: (Cross talking.) Exactly Evan Brand: One or two people out in the world
that are struggling with mood issues, I mean it’s an epidemic so how big of an epidemic
well that’s what I’m about to tell you. Dr. Justin Marchegiani: Awesome, so let’s
dive in. So we’re gonna be talking about mood issues. Now I kind of draw the line in a couple
different areas because there’s gonna be mood issues that are like all the time and you’re
gonna see this in men women and more women. You’re gonna see mood issues that are more
cyclical that are involved with their cycle whether it’s at typically it’s in the be,
sometimes at ovulation and usually throughout that luteal phase, that last part of a woman’s
cycle a week maybe three tool days to a week before they actually menstruate or bleed,
have the period that’s when you’re gonna see a lot of mood issues and that could be hormonally
based. So you have mood issues that are more cyclical than like an everyday kind of thing
there’s that number two blood sugar issues people that are on a reactive hypoglycemia
roller coaster and live their life on a blood sugar roller coaster that’s gonna be a problem.
Number three, just poor nutrition. Like you’re not getting enough B vitamins and magnesium
and amino acids in your body so you’re just – your diet’s just poor nutritionally it’s
not nutritionally dense to provide the building blocks, to make all the brain chemicals, and
then number four I would say is a malabsorption issue. Meaning, you don’t have the your digestion,
is it off, or you don’t have the digestive secretions because of infection or food allergens
or gut stress you’re not able to break down those nutrients so maybe the nutrients are
coming in but we’re having a deficit on the breakdown side if you will Evan Brand: Yeah, it’s not what you eat, it’s
what do you digest from what you eat. So you could have a Paleo diet yes, but if you’re
still on an acid blocker or you have some infection you could still be at a deficiency
of those amino acids that you need to manufacture brain chemicals Dr. Justin Marchegiani: Exactly, and then
number five but kind of dovetail with the female hormone issue, but that’d be more on
the adrenal stress side highs and lows in cortisol or cortisol rhythm issues. Now, I
would say a lot of women that have the cyclical issues probably have an adrenal issue, but
there are some people that may have all the time issues that are more Audrina based indoor
men may have adrenal based issues, and then connecting to that, I would say with me the
thyroid low thyroid hormone is commonly shows up as anxiety. They’ve done studies where
they’ve taken people with anxiety and mood issues given one group, lithium the other
group actual t3 and they found the actual t3 thyroid hormone saw some of the mood related
issues and better than the lithium did. So those are kind of the big four or five things
I’m trying to dovetail and we can connect any comments on that the brief over you Evan. Evan Brand: Yeah, so what symptoms are we
talking like when we say mood issues are we hitting, I mean we already did an anxiety
podcast, we could talk about depression and that’s part of it are we just saying mood
issues as a whole, I mean that could be irritability, that could be anger, I mean do we just tie
it all together because really it’s all connected. Dr. Justin Marchegiani: Yeah, your debility,
anger, anxiety, depression and then typically those things tend to dovetail with fatigue
I think the only if we’re unique most people that have fatigue tend to have those issues,
with the exception of maybe anxiety. I’ve seen some people that are very energetic but
are anxious kind of that tire but why are you kind of thing but they may not be like
fatigue so to speak. So typically you’re gonna see almost all of those issues have a fatigue
backbone with the exception of anxiety maybe but you can still be anxious and tired though
– Evan Brand: Yeah, so depression specifically
what I found here for statistics in the US about 10% of the US population has reported
depression, so I mean how many people are depressed that have not reported it probably
a huge amount. So you know if we estimate the US population over 300 million people,
10%, that’s what 30 million people, yes a lot of people, so you know not just you and
your brother and your sister and your cousin, no, I mean this is everywhere you go I think
the numbers are probably way higher than 10%. I think it’s just that people are not reporting
it you know, what are you gonna do like you’re gonna go to your doctor you’re depressed a
lot of people are catching on to the fact that all they’re gonna do is get a prescription
pad written form and in your intro you said nothing about a deficiency of depression medication,
you didn’t say anything about a deficiency of anti-anxiety medication, so people know
they know that’s the only supposed cure that they’re gonna get is those drugs and people
don’t want to do, I mean you and I talk to people every single day all day and a lot
of them do have depression and they know I can’t get help from conventional psychiatry
or doctors so then they come to us because they know there’s something else going on
it’s not just a pill that I’m missing to fix my depression it’s something underlying and
I had depression for I don’t know 10 years I mean as long as I could remember and my
mood started to lift significantly after I worked on my gut. Dr. Justin Marchegiani: 100% now looking at
a lot of medications acutely a medication may be necessary if you’re in a suicidal place
that that may make sense but you have to work with someone to get to the root cause. The
problem is most antidepressants that actually don’t work in the long run. What happens is
the dose has to be raised up and then as you increase the dose your chance of side-effects
increase and side-effects of antidepressants can be weight gain, it could be low libido,
it could be other mood issues, it could be energy issue, so there’s other issues that
could happen spinning off a various side effects. So like within the depressants we have SSRI
medications right that’s your selective serotonin reuptake inhibitors, these are like your pre
and post synaptic neuron you have all the the brain chemicals here in between the synapses
is like your serotonin and there’s react ape ports on the presynaptic neuron where these
chemicalsget recycled and a reuptake inhibitor it blocks this. So imagine putting my hand
over this part and that way these chemicals cannot go back into that presynaptic neuron
and if you guys are listening on podcast feel free and click below to see the YouTube links
that you can see my, my little hand puppetry if you will. So that’s kind of SSRI you have
SSNRI which is like Selective’s Norepinephrine Reuptake Inhibitor so SNRI. Now, looking at
norepinephrine dopamine which is similar you have things like wellbutrin, there’s other
medications that are in that category that are working more on adrenaline dopamine kind
of cascade because dopamine’s a precursor to adrenaline. So you have those medications
on the depression side there’s new lines of antidepressant medications coming out working
on brain inflammation. The conventional medicine is starting to understand that brain inflammation
is a big impact on mood so they’re giving you these medications to help with that. Now,
you got to be careful because anytime you don’t get to the root cause you create potential
side effects, so these medications are so new coming out not even sure if they’re even
from market yet they’re in the testing process now, so the side effects I’m not sure of yet
but I guarantee you there’ll be a whole bunch. Now, looking at functional medicine in nutrition
we want to get to the root cause of that brain inflammation, so one of the first thing we
look at is to diet and the first thing after that is the gut because inflammation in the
gut drastically causes inflammation in the brain, we have this the tight junctions open
up this leaky gut gastro intestinal permeability phenomenon occurs undigested particulate bacteria
foods gluten dairy get into the bloodstream, they can make their way up to the brain and
make an activate our microglial cells which can create more cognitive issues more brain
fog and more mood issues. So depression is a really big component so just kind of laying
out the medication here and then obviously we have like our our gaba like as a pain medications
which are gonna be working more on the gaba receptor sites and then we have ourold tricyclic
s–from the 80s which are antidepressants from the 80s, less side effects with those
but those still are kind of a weaker SSRI and — Evan Brand: Well the problem with the benzos
is that they’re highly addictive and if you try to come off of those you have a big withdrawal
period where there’s going to be potentially more anxiety, more depression, panic attacks,
I mean I’ve had people who come to me after they tried to go cold turkey off of a benzo
and they’re having night sweats and panic attacks it’s like no you can’t do that, you
know those drugs were really really effective so it’s just not something you can do on your
own, you really have to have a doctor to help get you off of those drugs and a big problem
is two people that are trying to mix supplements with medications – I mean you can’t just go
take a SSRI and then go take 500 milligrams of 5-htp that’s just not something that you
want to do it’s rare and I haven’t seen any cases of it personally but it’s called serotonin
syndrome and that’s when you can boost up serotonin way too much with the drug and a
nutrient so this isn’t. I mean when you’re talking brain chemistry you don’t want to
come in there and just go to Whole Foods, buy a bunch of amino acids and start popping
them if you don’t know what you’re doing Dr. Justin Marchegiani: Yeah, and the side
effects are pretty prolific like we talked about nausea, fatigue, poor sleep, dry mouth,
blurred vision, constipation, low libido, weight gain, so all of these things can, can
add to the milieu of symptoms that are already there and we’re not getting to the root cause,
so we kind of lead it the medications we talked about how important that is we obviously know
foods really important because foods where all the building blocks come from so we want
diets a very important very nutrient-dense with lots of good healthy B vitamins especially
b6 which helps activate a lot of our brain chemicals. So obviously like a paleo temple
it’s gonna be a great starting point with healthy organic green vegetables you know
lower sugar fruit lots of good anti-inflammatory compounds they’re good healthy omega-3 fats
which can help a brain inflammation and help with inflammation in general and lots of healthy
good animal products that are gonna be grass-fed not grain fed with all the roundup and pesticides
and junk. Evan Brand: Yeah. I’ve noticed a big difference
myself with the fish oil just taking that tends to just level my mood out it’s not like
it’s an any depressant effect like you would get from something like rhodiola, that’s one
of my favourite adaptogenic herbs for depression. It’s not that significant but it just kind
of makes you more even keel, where something like an adaptogen is going to help really
boost you and you’re gonna feel altered, almost like you have a buzz from the herbs like,
whoa I’m I feel happy I feel great. Yeah ___[10:57] is good for that gotu kola is good. I would
say ginkgo could be in that category too because ginkgo will help with the blood flow in the
brain, you know some of it could just be poor oxygenation what you think like if someone’s
sedentary and maybe they have poor circulation, maybe they have mold issues that’s blocking
nitric oxide, I mean how much of depression do you think is an oxygen related issue. Dr. Justin Marchegiani: Yeah, I mean anytime
you have poor or increased coagulation meaning blood is kind of viscous, it’s like molasses
things aren’t flowing well. Exercise helps improve that just getting inflammation down
when you’re more inflamed and you have more inflammatory cytokines or interleukins in
your bloodstream. Things get stickier and they’re not gonna flow as well, so movement
helps getting the inflammation down, helps doing things like ginger tea. Ginger can be
helpful. Fish oil is a natural blood thinner so you talk about fish oil. Part of the mechanism
on fish oil works is it helps that coagula, it prevents things from clotting and sticking
and also a fish oil is like a weak MAO inhibitor so basically, MAO is another kind of enzyme
that metabolizes a lot of these brain chemicals kind of naturally and this it has a way of
delaying that metabolism so not quite a drug like effect but it does have a mild effect
there and again when you do things that are more natural and have mild effects. You have
less side effects so fish oil’s wonderful with that also things like St. John’s Wort
has some really good depression antidepressant qualities too and a lot of times they’re working
on indirectly. They have anti-inflammatory effects they have which then helps with blood
flow which then they tend to have maybe a mild MAO kind of you know decreasing the metabolism
of our brain chemicals kind of mechanism that’s happening at play. Also one thing about gluten
they’ve done, studies on gluten where gluten decreases blood flow to the frontal cortex
so oh you have you know your garden hoses up the side of your head is called your carotid
they gave people basically functional MRIs and they looked at blood flow and activation
and the frontal cortex pre and post gluten and they saw significant reduction in blood
flow to the frontal cortex the neocortex which is what makes us humans compared to animals
and they saw a significant reduction and also significant reduction in migraines when that
blood flow was supported. Meaning, when they cut the gluten down migraine stopped and they
also saw that the blood flow was coming up when that happened so kind of outlined the
mechanism. Blood flow is a really important component so anytime we can decrease the coagulate,
meaning things sticking and we can improve the blood flow, like we talked about that
makes a huge difference now exercise helps with the blood flow it also helps stimulate
beta endorphin which is the natural antidepressant. It hits that opiate receptor and it’s a nineteen
amino acid compound, meaning you need to be digesting and having good protein so the more
you’re vegan and vegetarian and you’re not getting good quality proteins in there or
you’re not supplementing additional proteins and b12 as a vegetarian vegan in omega-3 from
algae you’re in a worse situation because you’re not getting those certain nutrients
in Evan Brand: Yeah, I’ve got my wife on some
herbs right now St. John’s Wort passion flower motherwort dandelion Damiana black cohosh
this is a kind of a postpartum mood remedy that we’re using that’s an herbal tincture
and I’ve tried it and I feel great. I feel a lift from it too. So, this is something
we’re doing for her just because you know a lot of depression we didn’t talk about this
yet, a lot of depression is postpartum but then it never lifts right you and I talk with
moms every single week. We’ll talk with the mom who says you know you and I will do a
history together we’ll say okay let’s go back in time when did this depression start or
when did this anxiety start. We’re always trying to make our timeline and so a lot of
moms will say, wow this was after my first kid or after my second kid or after my third
kid, the depression came on and it never went away and some of that steroid related because
we do see a lot of postpartum Hashimoto’s where all the sudden the immune system goes
crazy antibodies go up. The thyroid gets attacked the woman becomes hypo under functioning with
thyroid or maybe she’s alternating between hypo and hyper and then she’s feeling bad
because of that and so these herbs can come in and really help to regulate not only thyroid
function, you could do some adaptogens to help adrenal thyroid but then the mood ones
too like passion flower. I love it you know I think it’s something everybody could benefit
from especially if you’re more on the anxious side where you’re stuck in traffic and you’re
freaking out even my grandfather the other day he told me he said, Evan I can’t handle
traffic anymore, and my grandma starts making fun of them they were talking about how they
got stuck in rush-hour traffic and my grandpa was kind of freaking out kind of panicking
getting anxious and he never used to be like that. So I told him, hey maybe we can get
you a passionflower tincture. You put it in your purse, you know my grandma’s purse and
take a shot of that next time you get stuck in traffic Dr. Justin Marchegiani: Exactly, now some
natural ways that you can improve GABA levels is there’s some people to talk about GABA
is too small or too large to pass the blood-brain barrier, but yeah I don’t know I kind of go
back and forth on that so there’s that so you could take a product called Pharma GABA
and you can do with sublingually so I’m gonna take one now to kind of promote my parasympathetic
nervous system responses. Evan Brand: I love them. They’re great. I
chew them up too so great, great tasting. Dr. Justin Marchegiani: Anytime you’re supporting
adrenal stress right because GABA is the brake on the sympathetic fight-or-flight nervous
system so anytime you can kind of bring cortisol and adrenaline back into balance, it’s helpful
so things that you can do are gonna be ___[16:37] is gonna be excellent, magnesium will be excellent,
ashwagandha will be excellent as well that really helps curtail, let’s just say a lot
of the at the HPA access dysfunction. Evan Brand: Let’s go into magnesium a bit
because you hit that one but I don’t want to gloss over because magnesium is a huge
needle mover. Maybe let’s dive into just a couple different forms for people that they
could use. So last night I did some magnesium oil. I did some spray on my legs, my calves,
I started to feel a little cramp coming on I thought you know, I was in the sauna over
the weekend I was sweating I might not have replenished enough of my magnesium so I did
magnesium oil and I slept much better with the oil. So that’s one topical form and then
a lot of times you and I talked about magnesium glycinate, ___[17:23]I’ve had really good
success with ___[17:25] especially for like muscle relaxation. Dr. Justin Marchegiani: Exactly, so magnesium
is gonna be excellent. It’s a natural beta blocker so it can relax your heart so your
heart’s not beating out of your chest. Obviously there’s like a thousand enzymatic roles in
the body from magnesium so it’s in help with motility it’s in help but blood sugar metabolism
it’s in hell but inflammation in the brain I think part of the mechanism and how magnesium
works , ___[17:51] it’s highly anti-inflammatory to the brain. I saw a lecture with Russel
Blaylock who’s a famous neurosurgeon and he said clinically when he operated on people
and he would give them post-op stuck the metal magnesium they heal better than his colleagues
patients that had the same procedure, it was like a remarkable difference. He said so supplementing
additional magnesium really made a big difference. Evan Brand: Magnesium threonate, that’s amazing
magnesium threonate would be the other form I would recommend just because we do know
magnesium threonate and a-actually crosses the blood-brain barrier so when you’re talking
about gaba, you know supposedly being too big to cross the blood-brain barrier and the
pharma gaba is smaller and is more easily readily available to get through the barrier
same thing with magnesium threonate. So yeah if you do one to two grams of threonate that’s
going to get to the brain and you’ll feel significant changes, I mean we’ve used it
for people with PTSD. You know some of the literature we use professional healthcare
companies to manufacture our products and they’ll give us some text sheets on the back
end and they’ll have a whole list of symptoms why you would use threonate and PTSD and anxiety
is one of them so we know these people think of anybody who’s at a stressful or traumatic
event which is pretty much every human ever obviously some more than others. The threonate
to me is a good a good remedy I mean if I had like a a trauma clinic or like a PTSD
clinic or something or a mental health clinic where you know let’s say you’ve got people
having mental breakdowns, you know kind of back in the day like my grandmother her grandmother
would talk about oh if you have a mental breakdown you go to this hospital you stay in there
for a month and they send you home. I guarantee they weren’t using magnesium threonate because
it wasn’t invented back then but that would be something I would have in the protocol
for people rather than, yeah, automatically going to the prescriptions.
Dr. Justin Marchegiani: Yeah, I know Blaylock. I don’t even think Blaylock was using threonate,
back things it wasn’t really that big. Evan Brand: Yeah.
Dr. Justin Marchegiani: Using a standard citrate, probably citrate it’s fine. It’s a cheaper
version you can get it in natural calm, it can cause bowel, your bowels to move so some
people do better with the ___[19:51] or a or glycinate or if you know this cognitive
issues we can do a magnesium that is a threonate, that better at crossing the blood-brain barrier
we love that. Evan Brand: Yes, I wanted to give you a brief
diversion on the magnesium piece because here magnesium, but then they don’t know there’s
a lot of different varieties of it that have different effects . Dr. Justin Marchegiani: Mm-hmm yeah, exactly.
Now, next passionflower is great which is otherwise known as melissa officinalis. Another
great relaxing kind of herb. It tends to be almost like a natural. Evan Brand: melissa is a lemon balm. Dr. Justin Marchegiani: Yeah, oh yeah I’m
sorry yeah yeah, the same thing Melissa and lemon balm tend to be relaxing so a lot of
like natural hyperthyroid formulas have that in it so Melissa Melissa and lemon balm are
over here passion flowers is similar and then Valerians both sent when they didn’t have
relaxing kind of dampening effects and yeah, thank you. Evan Brand: Yeah theLlatin on because you
said passion flower, then you said otherwise Melissa yeah ,passion flowers Latin name is
like Pasi flora something and carnie incarnate, uh, something like that I don’t really. Dr. Justin Marchegiani: It’s, it’s lemon balm
and Melissa are the same thing yeah, flour and then valerian excellent also we can add
kava to the mix there’s been research on kava from the Cochrane Database. You know, finding
it’s very effective at helping with anxiety without the side effects so kava is excellent. Evan Brand: Have you tried kava?
Dr. Justin Marchegiani: I’ve tried it supplementally a couple times. I’ve tried it, someone made
me kava tea before, it’s big in Fiji I think it’s very helpful it basically activates those
GABA-A receptors is GABA-A and GABA-B and it really activates the A receptors in the
brain so it can really help kind of chill you out and relax you. Evan Brand: I went-I’m going to a kava bar
one time when I was down in Austin and drink a shot of it, it tasted like – it tasted and
looked like mud water. Dr. Justin Marchegiani: That’s exactly how
it tasted look, yeah. Evan Brand: And I was I was altered, I thought
man I don’t know if I’m gonna be able to drive home. I mean I’m really sensitive so maybe
my GABA system just got flooded but I was sitting back in the chair kind of like, whoa
I mean it hit me like a ton of bricks. Dr. Justin Marchegiani: I’ve also seen CBD
do very well in the mood side too so that’s ___[22:01] with the non active THC has, I
think is very helpful too I always tend to lean more on nutrition first, so like the
B vitamins, b6, magnesium ,will also do higher dose l-theanine amino acid which can help
promote GABA production stuff the mental gammas I tend to promote those along with the long-standing
adaptogens that have a long term success record, like ashwagandha is excellence I’d say Kava
after that’s wonderful lots of studies on it and then- um-any comments on that before
we go to the next step? Evan Brand: Yeah CBD has been helpful for
me too. I give it to my daughter so if she complains of a headache or a bellyache or
if she seems restless at night we’ll just give her a one milliliter dose which the brand
I carry is a 10 milligram CBD, she’ll go right to sleep so it’s a really good settling thing
and so for kids too. I mean I didn’t mention the statistics I was looking at some of this
stuff from the Center for Disease Control. I mean we’re seeing we’re seeing 20 to 30
percent of children now are reporting anxiety and depression so I have moms that are telling
me their kids are suicidal at 5 10 years old. I mean, when I was 5 and 10 years old I had
no comprehension of death or mortality so I don’t know if it’s you know the the TV shows
and the violence that kids are exposed to in other places that I wasn’t because I was
outside on my bike all the time or what but you know as a kid I don’t remember other kids
being anxious and depressed. Now I mean it’s almost every single kid that I see there’s
an underlying anxiety problem associated with as you mentioned the gut you know we see these
kids eating conventional food or get tons of glyphosate they’re good bacteria killed
off the bacterial overgrowth are making toxins which are depressing and causing anxiety and
the kids, so I mean there is a root cause for the kids too. It’s not where they need
to be put on medication immediately same thing with ADHD. ou know these kids are getting
diagnosed with ADHD we see that get better with fixing the gut to 100% and there’s herbs
for kids too so there’s actually I mean, technically we can just dose adult formulas down but there
are some special kids formulas that we do use that are specifically maybe they have
a glycerine base as opposed to an alcohol base and passionflower skullcap, things like
that you can use those with kids as well. Dr. Justin Marchegiani: 100% also there’s
something called people, may know it call phenibut or for amino 3 phenol butyric acid.
Now this components a little bit controversial because there’s, there can be some addictive
qualities to it it’s essentially a GABA agonist. Supposedly crosses the blood-brain better
it’s a GABA agonist I’ve had some people that had phenomenal results with it ,but I’ve seen
it I’ve seen it become a little bit more addictive and people become dependent upon it so it’s
one of those things as a double-edged sword. I would never go to it first but I’ve seen
people that have done very well with it I think it would probably be better than peeing
on a benzo long term but I would always try that, that mean the last thing I would potentially
ever go to in my arsenal because of so the so-called some addictive qualities to it Evan Brand: Yeah, I mean it helped, it helped
change my change my life and get me through some tough times but, yeah, there’s a huge
risk with people not respecting it and overusing it and down regulating GABA so much that you
get more anxious you get more panic etc. When you try to get off of it whereas the pharma
GABA that you just chewed up you’re not gonna have that potential for that one. Dr. Justin Marchegiani: Exactly, yeah, exactly,
so we have a lot of the supplementation I would also say if it just depends – because
if we have a high cortisol state things that can help lower cortisol make a big difference.
Some people have a very low cortisol state and some of their anxiety and mood issues
is driven by low cortisol so some people think it’s like, hey this is the solution for that,
well it really depends because what if you have low adrenaline and low cortisol well
a lot of your anxiety and mood stuff could be from the lower state versus higher anxiety
and high cortisol or higher adrenaline and high cortisol be many things to bring it down
so we may be doing things more like phosphorylated serine to bring it down and actual gana we
may do things to bring it up that are more stimulating like ginseng or licorice if it’s
chronically low, and or tyrosine if we see low adrenaline so we got a look at what the
pattern is because sometimes extreme high and lows can feel the same and that’s hard
people to wrap their heads around. Evan Brand: Yeah that’s a good point. I mean
I had a woman in college who she, she was in Hawaii I remember that we found out her
her dorm was super moldy and that’s why she was having all these panic attacks so that
was cool too, but she had extremely, extremely high cortisol but just based on doing the
initial intake and we talked over her symptoms. She was exhausted couldn’t get out of bed
etc, we thought, oh my god I bet her cortisol has flatlined, no it was the opposite it was
very sky-high so this is why you know you listen to a podcast you think, oh I’ve got
low cortisol I’m tired I’m gonna go take a bunch of licorice, no way if we would have
given that to that girl with high cortisol we would have made her blood pressure go up
she would have had more anxiety more panic so this is why you have to test you don’t
want to guess with this stuff you really want to get the data, maybe we should talk about
that now do you think we should move on to testing. Dr. Justin Marchegiani: Yeah so I would say
off the bat right we got to make sure the guts functioning well right the absorption
of these nutrition where inflammation kind of gets into the bloodstream and goes to the
brain really depends a lot on gut inflammation so good high-quality stool testing. I know
we talked about doing the GI map task we like there’s a couple others that we do as well
but if someone wants to dig in deeper to the gut we have to really fully assess that. Evan Brand: Yeah so the guts huge urine I
mean you’re in great we test for micro toxins through urine we test for chemicals we test
for amino acid metabolism we test for bacterial overgrowth and Candida which can affect the
mood so getting a urine test will be key and then getting the saliva adrenal test or a
urine I don’t know do you do salivary adrenals anymore are you just doing urine Dr. Justin Marchegiani: I know sometimes salivary
adrenals but I’ve been liking the urinary metabolites because I see a lot of women that
have a hard time metabolizing estrogen, so it’s nice to be able to run that one because
I can also see how they’re metabolizing the hormones too. So that totally helps if you’re
a female and you have estrogen dominant issues. So I maintain a new right estrogen dominance
right that that ratio of progesterone estrogen drops right progesterone and estrogen drop
like this. Meaning everything drops but progesterone drops faster so it’s nice to be able to see
that because that can be a big mood issue – remember progesterone is a natural GABA
chloride channel opener meaning we can promote GABA in the brain with healthy levels of progesterone
so part of your GABA issue could be lower progesterone as a woman and also progesterone
is very anti-inflammatory in the brain even with men with like concussions or any brain
trauma they’ll give a couple hundred milligrams of progesterone for a few days after brain
trauma to actually curtail the inflammation in the brain, so progesterone is very anti-inflammatory
because of its cortisol building block effects of progesterone can help brain inflammation
in brain trauma. Evan Brand: Now let’s go a little further
then are you talking supplementing progesterone, are you taking, doing some of these specialized
maca extracts to help regulate progesterone estrogen? Dr. Justin Marchegiani: Both no, but it depends
on how bad it is. If it’s slightly out of balance we always lean to herbs and diet and
natural components, if it’s significantly out of balance will use the bioidentical plant
base and we’ll dosed it accordingly to accelerate the results. Evan Brand: Okay and then like estrogen dominance,
you’re talking removing plastics removing phthalates and other things from the makeup
and environment. Plus maybe you’re gonna be throwing in some herbs to help regulate that
maybe like the do you pronounce it ___[29:41] Dr. Justin Marchegiani: Yeah ___[29:42] more
gonna help on the testosterone side, but on the inside we would do more like calcium to
___[29:47] and all methane, fiber. Right these things are really helpful also there’s some
some seed protocols where they’ll, do they’ll, do what’s the seed-
Evan Brand: Alpha linoleic acid omega-3 flax Dr. Justin Marchegiani: Yeah exceed in the
first half of the cycle so f for first half of the cycle and then typically a lot of sesame
seeds for the second half of the cycle F &S; sometimes they’ll throw some pumpkin seed
in there as well and that can help bind up some of the estrogen metabolites too. Evan Brand: Oh interesting I was going to
say I was reading some studies over the weekend about detoxing mycotoxins and actually one
of the suggest that things to do was take flaxseed to help bind to toxins so that’s
pretty cool it’ll bind the excess estrogen as well. Dr. Justin Marchegiani: Yeah I think that’s
in our ___[30:36] buying product too isn’t it?
Evan Brand: Yes, Dr. Justin Marchegiani: Exactly, so that’s
really good for mycotoxins and mold and then we already kind of dovetail through the mold
mycotoxin coagulate issue it’s in a decreased blood flow so if you have any mold or environmental
stuff that could easily be affecting how the blood is flowing to the brain and obviously
potentially even getting to the brain and activating those microglial cells – that’s
very possible. Evan Brand: Yeah I’ve got a story people like
stories right so we get into the geekiest and then people like zone out on us so here’s
a here’s a quick stor.y I was working with a teacher last week she’s in her sixties she’s
about to retire and we were discussing her urine test we looked at her urine for mycotoxin.
She had a lot of different mold problems and I gave her some of these little plates these
little petri dishes and we took him to her school she put him in her classroom. Her classroom
came back very moldy and she goes, oh my god. you know this explains why after summer break
you know all the teachers leave they come back and she says her and all of her colleagues
talk about how they get depressed they get fat they get tired they get anxious etc, when
they come back to school. Now obviously people would say, oh it’s just the kids stressing
them out, no it’s she’s getting out of the moldy environment. For the summer the mold
grows there in the summer they probably don’t run the air conditioners because they’re saving
money on budget. during the summer they come back school starts in August or whenever and
then they get sick again but luckily in her case she’s retiring so it didn’t matter but
this is a real issue with a lot of women in office buildings or school buildings if you,
if you feel worse, if you feel more tired, you feel more depressed etc when you go into
a certain environment that might not just be the stress of the job or the bad boss this
could be a toxin or pollutant in there so you may need to get like a HEPA filter in
your classroom or a portable HEPA filter to put on your desk. if you’re in a cubicle and
you’ve got people wearing perfume and stuff around you right you may need to try to make
yourself have a little healthy bubble if you can’t leave or fix the environment that you
have to work in. Dr. Justin Marchegiani: 100% also be on top
of your environment, so we’ve already done plate testing in your house, in my house,
my basement, my new office. And my basement tested great for mold but I’m noticing that
the humidity contents going up as we get closer to the summer so like my first two floors
it’s like 43 44 % but then my basement where my office is is that 56%. Now the problem
is I would run the air conditioning more to knock it down but the problem is it’s already
sixty five degrees right now it’s already kind of cool because of you know the nature
of basement so because of that because I’m on top of it I’m gonna be getting a whole
house dehumidifier. Specific for basement dwellings to remove the humidity from the
air that way I don’t have to drop the temperature I can keep the temperature where it’s at and
just suck the moisture out of the air and drain it out so based on your feedback, I’m
already on top of that and everyone listening, if you have if you have a moldy environment
or any environmental symptoms but there are no leaks check the humidity content of your
house. Evan Brand: Yeah it sounds like we’re coming
out of left field, like okay we’re talking about GABA supplements now we’re talking about
your environment. Your environment it’s a huge piece of I mean, think of how much time
you spend indoors, it’s like what ninety five percent of your day. Most people are indoors
so the air you breathe can affect your nervous system we know just based on looking at the
EPA’s work where they’re sampling the homes that live near highways we know that the pollution
from a major highway gets into the home and that actually increases cortisol so you actually
have a shorter life span if you live close to a major highway or a busy road or a busy
intersection they’ve done. Studies on people that live near four-way stop signs and four-way
traffic lights and if you live near those busy intersections the cars are breaking the
brake dust gets into the air it goes into your home it contaminates you know your children’s
lungs your lungs etc so if you’re in a busy area and even if you’re not in a busier. I
mean, here’s the deal, you know I’ve got five acres, I’m out in the country but we still
have bad air quality because of the way the wind blows and so when the summer starts heating
up the pollutants from the car exhaust will have air quality alert days all the time during
the summer so that’s the time where you want air purifiers in your home, in your space.
Making sure your airs clean now if you go outside and play sure you’re going to get
exposed to the crap, but if you’re in your home you need it to be a sanctuary in terms
of free of extra EMF free of mold free of extra humidity free of pollutants you know
this is very, very critical especially your bedroom. Dr. Justin Marchegiani: 100% that’s why we
recommend also high quality air filtration as well if you go to my site justinhealth.com/
shop, you can click on the recommended products tab and look at some of the products that
I recommend, that I personally havem I have multiple same thing. If you go to evanbrand.com
and click on his store button, he has similar products that we both recommend and talk about
and share with each other but if you guys are enjoying this cause and that’s a great
way to support us so you can get great products we’ve already tested for y’all. Evan Brand: Yep, yeah we’ve got like four
different brain. I’m always experimenting so we’re trying to get you the best of the
best. There’s a lot of crap out there like if you go to Target or Walmart and you go
buy a air purifiers thats better than nothing, yes, but is it the best of the best? Probably
not, no. Dr. Justin Marchegiani: Exactly. Evan Brand: You get what I pay for you, get
what you pay for. You can go buy a $50 HEPA filte.r but you know, I buy more like $500
HEPA filters but they’re you know they’re built like a tank and they’re quality so- Dr. Justin Marchegiani: Yeah it’s kind of
we are getting like almost a surgical base kind of air filtration. Evan Brand: Yeah it’s like a hospital in my
house in terms of the, the air purity not the not the Candida everywhere on the walls
that is affecting people. Have you read about that the candida like ___[36:06] outbreak?
It’s very dangerous. Yes, yes I’ve seen that it’s pretty bad. Evan Brand:Hhospitals don’t know what to do.
I mean they’re, they’re running out of options, you know the antifungal drugs are not working. Dr. Justin Marchegiani: Yeah they need to
be using more silver and probably even more specific probiotics because I think a lot
of these Candida things are coming potentially from people post antibiotic supplementation
or post probiotic prescription so I think the components big also, I know surgically
my mom’s a surgical nurse for 45 years they’re using a lot more silver, now they’re wrapping
all joints in like a silver cellophane after surgery to prevent MRSA an issue, so silver
is already being used at that surgical level. Evan Brand: Good, good yeah we still need
more help though, I mean when the center Disease Control says, hey basically don’t even go
in a hospital unless you have to, I mean, that’s pretty scary. Dr. Justin Marchegiani: Oh yeah like if I
have to go somewhere, I’m, I’m calling a doctor and going directly in paying cash or I’m going
to an urgent care place where you’re kind of in and out versus the conventional ER forget
about. Evan Brand: It, it’s just not it’s just not
safe so you know obviously the, the hospitals are there sometimes we have to go there but
when we’re talking about mood related issues. I mean you could have something as simple
as a panic attack, you think you’re dying because if a panic attack you go to the ER
and then they go run a bunch of tests on you and send you home with anxiety prescription
and nothing was wrong and now you expose yourself to all these pathogens in the hospital and
you come home more sick than you went in that’s just not a good thing to do. Dr. Justin Marchegiani: Exactly, yeah, 100%
same, and today was a great podcast, is there anything else you want to, to the show here? Evan Brand: The last thing blood sugar. We’ve
done so many we always talk about blood sugar but I just forgot to mention it because when
we talking anxiety, mood issues there’s so many pieces of the puzzle when I feel low,
if I feel depressed, if I feel anxious, if I feel like oh my heart’s starting to race
a little bit, I’ll go prick my finger and sometimes I’m at – at like a 68 on my alt
my glucose. Is just too low I’m getting that adrenaline response which is driving anxiety
so I mean, don’t you know we got so many people practicing intermittent fasting and doing
low carb diets etc, and these people depending on the, the stress and their life they may
be less tolerable of lower carb less tolerable of intermittent fasting meaning a intermittent
fasting was too stressful so I just currently don’t do it and I was noticing that I felt
more anxious on those fasts and so for me blood sugar stability is a huge component. Dr. Justin Marchegiani: Yep I 100% agree and
if you guys are liking this content give us the thumbs up, smash that like button and
hit the bell as well so you can get notifications. I’ll be doing a live thyroid reset summit
QA for all the people that were involved in the thyroid summit so if you guys are enjoying
this I am set to go live here another 40 minutes we’ll be taking only thyroid Q&A; topics anyone
listening to this as well head over to thyroid reset. Some of oumake sure you subscribe there
as well. Evan, anything else? Evan Brand: Our plugs people have these issues
every day all day these are things we work with every day all day ,so if you want help
from Justin please reach out to his website justinhealth.com you can schedule a call from
around the world. For me my site is evanbrand.com. We don’t care who you work with as long as
you get the help you need we’re just happy to be, a be of service to you guys. Dr. Justin Marchegiani: Yeah 99.9% of people
that we help be never either me cuz they get access to our free content and they start
utilizing it and then some need you know deeper more hand-holding and deeper assessment so
that’s why we’re here and glad that everyone is enjoying the podcast and we’ll be back.
Evan take care Evan Brand: You too, take care bye
Dr. Justin Marchegiani: Take care, bye.

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