Improving Mitochondrial Function | Podcast #222

Improving Mitochondrial Function | Podcast #222

Dr. Justin Marchegiani: Hey there it’s Dr.
Justin Marchegiani. Today, we have Dr. Tim Jackson in the house,
we are doing a podcast on mitochondrial health, how to improve your mitochondria. Dr. Tim, welcome to the podcast my man! Dr. Tim Jackson: Dr. Justin, thanks for having
me. It’s always a pleasure. Dr. Justin Marchegiani: Very good. Well, what’s going on there? We were talking about some genetic test, uhm,
pre-called with one of my patients, you gave me some good feedback, I appreciate that. Let’s dive in to some genetic markers that
we can look at to maybe gleam a predisposition for having some mitochondrial stress or dysfunction. What would those be? Dr. Tim Jackson: Yeah. So, uh, looking at superoxide dismutase or
SOD- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -polymorphisms, uh, along
with polymorphisms in the glutathione pathway, whether it’s uh, GSTN uhm or GPX, uh because
both glutathione and Superoxide Dismutase are the two bodyguards that sit in front of
your mitochondria. Uhm, our nuclear DNA is protected by histones
and so is not as susceptible to oxidative damage. Dr. Justin Marchegiani: And what are histones? Dr. Tim Jackson: Histones are just proteins
uhm, that help, uh, kinda coil up uh- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -the DNA, and uh, organize
it and also protect it. Uh, and mitochondrial DNA uh, does not have
those, so it’s kind of sitting out uh- Dr. Justin Marchegiani: Aah… Dr. Tim Jackson: -alone by itself. And if you’re deficient in glutathione and
superoxide dismutase, then uh, it’s much easier for the mitochondria to become damaged. Dr. Justin Marchegiani: So regular DNAs has
histones which protect that coil up around the DNA, but mitochondrial DNA does not have
histones that make it more vulnerable, is that correct? Dr. Tim Jackson: Right. Dr. Justin Marchegiani: Ok, got it. So, what does that mean? What can we do to protect our DNA on the mitochondrial
side, uhm, form oxidative stress and damage? Dr. Tim Jackson: Well, obviously, you know,
looking at things like stealth infections, mold, dysbiosis, blood sugar imbalances, all
of those uhm, will create inflammation and ultimately stress the mitochondria- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -uh but in order to, you
know, protect it and upregulate the SOD compound or superoxide dismutase and glutathione, uh,
we can use things that upregulate NRF2. And NRF2 is just uh ce- cellular control switch,
uhm that is responsible for detoxifying, uh, certain compounds- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -but also upregulating your
antioxidant, your endogenous antioxidant production. So if we can do things that control many different
reactions- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -that’s a lot better than
going, you know, tip-for-tat, trying to uhm, you know, correct imbalances. Dr. Justin Marchegiani: Okay, got it. So let’s repeat those nutrients. So, obviously, superoxide dismutase is a-
is a big one, and where can we get that supplementally? Dr. Tim Jackson: So, there are several companies
that have uh, SOD, uhm, in the capsule or tablet. Uh, I haven’t seen any good data on how terrible
it is, uhm, so, I try to do things that will upregulate it upstream, uhm, instead of just
uh, you know, trying to absorb even in the uh- and optimally helping gut, I don’t know
how will absorb SOD would be. Uh, but if you upregulate NRF2, and things-
plenty of things can do that. Uh, but one that’s specific to the mitochondria
is molecular- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -hydrogen. And molecular hydrogen- what makes it so unique,
is that it’s- Dr. Justin Marchegiani: Hmm. Dr. Tim Jackson: -really tiny. So it can get to where we need it to go, which
is in the mitochondria. Dr. Justin Marchegiani: Got it. Dr. Tim Jackson: It- it helps to stab in the
nasty- really nasty free radical called peroxynitrite. Dr. Justin Marchegiani: Yes. Dr. Tim Jackson: And not only that, it stimulates
the production and creation of new mitochondria, which the only other things to do that are
exercise and PQQ. Dr. Justin Marchegiani: Excellent, very good. What about fasting? How much does fasting have an impact on the
mitochondria? Dr. Tim Jackson: Uh, it has a tremendous impact
uhm, in terms of upregulating, you know, autophagy, cleaning the cells- Dr. Justin Marchegiani: Yeah. Dr. Tim Jackson: -uh, that sort of thing. Uh, the only thing I would caution with fasting
is that, you know, if someone’s HPA, thyroid, gut, vanadyl axis [crosstalk], and uh, you
fast, then that may in fact worsen their metabolism and metabolic rate. Dr. Justin Marchegiani: And that’s a thing. I see a lot of people with adrenal issues
and also thyroid issues, and they may even have some blood sugar stuff, and they’re hearing
all the rage of fasting that people getting lots of benefits but that may actually exacerbate
their issues, right, it can increase the HPA-TA, or, you know, increase that stress and it
can even potentially lower thyroid hormone more by increasing reversed T3. Dr. Tim Jackson: Right, yeah, absolutely. And uh, lot of times, you know, you can develop
hypothyroid symptoms- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -uhm, adrenal insufficiency- Dr. Justin Marchegiani: Right. Dr. Tim Jackson: -and/or cortisol resistance. Dr. Justin Marchegiani: Totally. Good. So, we have- you mentioned- was that the molecular
hydrogen you mentioned- you mentioned the superoxide dismutase, correct? Uh- Dr. Tim Jackson: Yeah. Dr. Justin Marchegiani: Err- what about various
compounds like resveratrol or curcumin, what do you think about them? How do they do with the mitochondria? Dr. Tim Jackson: So, curcumin works on uh,
control switch called NF-kappa-beta. And basically, uh, you know, genes generally
aren’t turned completely on or off, it’s more- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -like adjusting the volume
on your stereo. And so, curcumin helps downregulate NF-kappa-beta- Dr. Justin Marchegiani: Got it. Dr. Tim Jackson: -and that results in less
inflammatory markers which is- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -cytokines- Dr. Justin Marchegiani: Right. Dr. Tim Jackson: -uh, TNF-alpha, ___[05:48]. And so, curcumin, uh, works, uh, on several
levels. It upregulates glutathione by up to 600%- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -uh, it downregulates NF-kappa-beta,
so- Dr. Justin Marchegiani: Right. Dr. Tim Jackson: -you’re not giving the inflammatory
stress. And that’s also has some antimicrobial properties. And, uh, not to get too far off topic but
certain viruses can get- retroviruses can get stuck in the mitochondria. And if- if you have a patient, or if you’re
someone who- you’ve been taking a lot of CoQ10, you’ve been taking lot of carnitine, you might
even have done IV-NAD, and you didn’t felt benefit, then it means your mitochondria are
damaged and we need to repair them. Uhm, and you tell me when you want me to go
into the three pronged approach of how to heal the mitochondria. Dr. Justin Marchegiani: That’s great, excellent. So is there anythi- other supplements you
can- you can highlight before we dive into that? What about resveratrol? People have talked about that. What’s your take on resveratrol? Dr. Tim Jackson: Yeah, uhm- it- it’s not very
absorbed, uhm- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -by most companies. Uhm, you know, even if you add uh- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -___[07:01] to it, or black
pepper. Uh there was a company that had transdermal
resveratrol- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -but I think the vinyl FDH
shut them down. Uhm but I think there are a few products out
there uhm, that have liposomal resveratrol. Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: And so, you know, that would
be better absorbed, for sure. Uhm, but yeah, I mean, it works on multiple
levels, it can help, you know, with hormone metabolism, uhm, and free radical stress- Dr. Justin Marchegiani: Hmm. Dr. Tim Jackson: -anti-aging, so many things. Dr. Justin Marchegiani: Very cool. Any other supplements you wanna highlight,
kinda low-hanging fruit nutrients, you wanna make note of? Dr. Tim Jackson: Uhm- B- well, I would say,
you know, L-carnitine, or Acetylcarnitine. Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: Uhm, you know, if you had
certain polymorphisms, you might not be able to carry fatty acids into the mitochondria- Dr. Justin Marchegiani: Mmm. Dr. Tim Jackson: -where they get burned for
energy- Dr. Justin Marchegiani: Right. Dr. Tim Jackson: -what we call beta-oxidation. Dr. Justin Marchegiani: Right. Dr. Tim Jackson: And so Acetylcarnitine is
like an uber for fatty acids- Dr. Justin Marchegiani: American shuttle. Dr. Tim Jackson: Yeah. Exactly. And so, you know, that’s a supplement that
uhm, helps mitochondrial health, helps improve metabolism, uhm it can help burn fat, uhm,
energy production, etc. So, yeah, I would say that- that’s definitely
low-hanging fruit. Uhm, and then, you know, the molecular hydrogen,
you’re not to harp on that too much but it- it does so many different things. Uhm- Dr. Justin Marchegiani: How do you get the
molecular hydrogen? I know you mentioned Cindy Crawford has a
skin-care line with those compounds in it. I know you mentioned there’s a molecular hydrogen
machine that you’ve been supporting and using for a while. Dr. Tim Jackson: Yeah. Dr. Justin Marchegiani: How we can get more
molecular hydrogen into our body? Dr. Tim Jackson: So, uh, the company trusii,
T-R-U-S-I-I, uh, there’s many companies offering molecular hydrogen machines. But this company, uhm, they have a- a really
great machine, uhm depending on how much you’ll wanna spend, uhm you just add reverse osmosis
or ___[09:08] as water. And it’s- uhm, add some molecular hydrogen
to it, uhm, so you don’t have to keep buying out the supplement, you know, every month. It’s a better alternative investment in my
opinion. Uhm, the more expensive machine also contains
a nasal cannula- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -so you can breathe that
in, uhm, and molecular hydrogen. So the highest concentration of mitochondria
is in our nervous system. Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: The second co- highest concentration
is in our heart. Uhm, and so, by improving uh, mitochondrial
function, we can improve brain health, brain fog, fatigue, uhm, you know, difficulty concentrating,
and also, uhm, have better for fusion to our tissues, because we have better cardiac output. Dr. Justin Marchegiani: Oh, interesting, very
good. Awesome. Uh, one thing I wanted to highlight too, you
were talking about carnitine a minute ago. Carnitine is important because there’s key
amino acids you need to make it. Methionine and lysine are really important
ones, and a lot of those amino acids are missing in vegetarian type diets. So if you’re not eating animal products, we
are not getting supplemental amino acids while being vegetarian, it may be hard- you’d be
missing some of those key nutrients that are important for making carnitine. [Crosstalk] Dr. Tim Jackson: Yeah. I mean, absolutely. And the process of methylation, uh, which
is you know, collection of a hundred and- or almost 200 different uh reactions in the
body. Uh, helps reduce CoQ10 and the L-carnitine. And so if you’re deficient in B12 or methyl
folate, or your methylation cycles disrupted because of uh heavy metals or environmental
pollutants, then you won’t create as much endogenous uhm L-carnitine and CoQ10. Dr. Justin Marchegiani: Interesting. And can you talk more about methylation. So, a methyl group is a carbon in 3 hydrogen. So essentially hen we methylate, we’re just
binding those compounds, uhm, to whatever that reaction is, whether it’s neurotransmitters
or B-Vitamins. Can you talk kinda more about it like, what
does that really- what’s really happening kinda at a biochemical level inside of our
cells when we’re methylating and- and where does this happen? Dr. Tim Jackson: Uh, so it happens uhm, and
all the cells in the body and it involves no just B12 and methyl folate but all the
other B-Vitamins, as well as- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -mineral cofactors such as
magnesium and zinc. Uhm, and- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -you know, you probably heard
of supplements like TMG or DMG- Dr. Justin Marchegiani: Yeah. Dr. Tim Jackson: -uhm, those are- Dr. Justin Marchegiani: [Crosstalk] Dr. Tim Jackson: -yeah those are major methyl
burners uhm that have been shown to improve cognitive function. Uhm, but methylation is responsible for everything
from detoxification, to producing glutathione to uh, producing certain immune cells, the
CD4, CD8, T-helper, T-suppressor cells. Uhm, and also, metabolism of your estrogens. So- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -if you’re not methylating
your estrogens, you tend to recycle or reabsorb them. And uh, you know, methylation can get turned
off, uh, independent of any polymorphisms, you know. But if you have polymorphisms and uh methylation
or MTHFR, then that certainly uhm, you know tells us that you at some point, you know,
in the right context, need both B12 and methyl folate along with the other B-Vitamins. Dr. Justin Marchegiani: And so what’s happening
in the body? These nutrients are- are- they’re affecting
obviously brain chemicals or affecting detoxification like, what’s happening? Like, just to keep it simple. Dr. Tim Jackson: Yeah, so, basically adding
a methyl group, uhm, helps with the creation of glutathione, but you’re also getting neurotransmitters
like ___[12:54] Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -to turn into dopamine, produce. Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: Uh, there’s a condition called
cerebral folate deficiency, where uh, due to certain antibodies, uhm, you might have
uh, enough, uhm methylfolate or folinic acid in your cells but it might not be in the cerebral
spinal fluid. Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: And uhm there are a couple
labs I think that test for it now, it used to be mostly research-based, uhm but those
people to need higher doses of methylfolate- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: Uhm with the other thing
with uh B12 is that it needs a- a transporter, a mover. So, lithium orotate, the trace mineral, not
the psychotropic drug but, it helps uhm transport vitamin B12. Dr. Justin Marchegiani: Oh, very cool. I know you mentioned that on- on our last
podcast we did together. That’s very good. So we have this carbon-hydrogens, then we
need all these nutrients, trimethylglycine or- or HCL, essentially betaines gonna have
a lot of that in there. Our methylating B-Vitamins like B6, B9, B12,
ideally, we’re having uhm folate, not folic acid, we’re having methylated or LMTHF folate,
we also may be doing choline like B1, like riboflavin, thiamine, nycine as well. Dr. Tim Jackson: Yeah. So, uhm all the B’s, biotin, etc., uhm all
need to be there for the methylation cycle to occur. Uhm, and, you know, you could- there are many
polymorphisms that we won’t give into that can affect the methylation cycle outside of
MTHFR. Uhm, so, you know, it’s really ab- about the
environment and the terrain that determines whether these- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -polymorphisms expressed
or not. Dr. Justin Marchegiani: Very cool. Alright, so let’s go dive into your 3-prong
approach. So, what does that look like and- and how
do you apply that clinically with your patients? Dr. Tim Jackson: Yeah. So, basically, err, we’ve been taught that
you know, okay, give more CoQ10, give more carnitine. Dr. Justin Marchegiani: Yep. Dr. Tim Jackson: And let- let’s say you have
a ferrari, and the transmission’s out. Putting more gasoline in the gas tank is not
gonna help the- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -transmission. And that’s what you’re doing when you’re just
giving CoQ10 or carnitine. And that’s okay uh, but you have to adjust
the other aspects and one of them we mentioned earlier, and that’s uh, protecting the mitochondria. How do we protect them? We make sure we have adequate glutathione,
reduced glutathione, not oxidized glutathione, and uh optimal levels of SOD or superoxide
dismutase. Dr. Justin Marchegiani: Interesting. Okay, got it. Dr. Tim Jackson: And so, the 3-pronged approach
is protect the mitochondria, the antioxidants, provide mitochondrial fuel, you know with
L-carnitine, CoQ10 etc.- Dr. Justin Marchegiani: PQQ. Dr. Tim Jackson: PQQ, NAD, uh nicotine ___[15:47]- Dr. Justin Marchegiani: Yup. Dr. Tim Jackson: -a- all those things. And then the 3rd of uh aspect or 3rd uhm,
prong of the approach is to repair the mitochondrial membranes. And so those get damaged from inflammation,
and also certain pesticides and petrochemicals, and uhm, you can use different supplements
uhm that have high doses of phospholipids, uhm, ___[16:14] in them to help remodel the
mitochondria, and uh, you know, it’s been studied in patients with chronic fatigue syndrome,
uhm to help the mitochondria for sure- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -uhm, so the 3 pronged approach,
just to summarize is, protect the mitochondria with glutathione superoxide dismutase, repair
the mitochondrial membranes with uhm NT factor energy, or uhm, uh group of phospholipids
that are gonna rehab or rehabilitate mitochondrial membrane, and then provide mitochondrial fuel
via CoQ10, carnitine, PQQ, NAD, etc. Dr. Justin Marchegiani: Got it. So, repair, protect, and fuel. So, protection is glutathione, antioxidants. Would curcumin also fall into that category
too? Dr. Tim Jackson: Curcumin, uhm helps to upregulate
glutathione- Dr. Justin Marchegiani: So I guess it could
right ’cause glutathione’s uh antioxidant. So, would it kinda have some protection qualities,
right? Dr. Tim Jackson: Yeah, absolutely. And because it lowers uh inflammatory markers- Dr. Justin Marchegiani: Yeah. Dr. Tim Jackson: -uh that’s gonna put less
oxygenated stress on the mitochondria- Dr. Justin Marchegiani: Good. Excellent- Dr. Tim Jackson: -and- Dr. Justin Marchegiani: -so that’s the protection. Then on the fuel, that’s like B-Vitamins,
CoQ10, carnitine, PQQ and then with- with like the niagen or the- the nicotinamide compounds
fit into that category? Dr. Tim Jackson: Uh they- uh could uh potentially
but I think of them more as uh mitochondrial fuel. Dr. Justin Marchegiani: Oh that’s more- yeah,
fuel, that’s in- in that fuel, yup. Correct? Dr. Tim Jackson: Yeah. And so, uhm you know, the- they can definitely
help and you know, in the clinic we’d use uh IV-NAD, it’s great for uh drug detox- Dr. Justin Marchegiani: It burns though doesn’t
it? Dr. Tim Jackson: Uh, it should be between
a 6- and 8-hour drip, and you have to do it 10 days consecutively, you can’t miss a day. Uhm, and that can help for example people
who’d take in the antibiotics that fall under the 4-Quinolone- Dr. Justin Marchegiani: Oh yeah. Dr. Tim Jackson: [Crosstalk] Dr. Justin Marchegiani: Lot of damage. Dr. Tim Jackson: Yeah, lot of damage. So, IV-NAD, coupled with the NT factor energy,
uhm can help the mitochondria for sure. Dr. Justin Marchegiani: And then on the- so
you have the repair side which is like a lot of the- so we have the protect which is lot
of the antioxidants, the fuel is more of the nutrients we just mentioned, the NAD, the
B-Vitamins and CoQ10, carnitine. And then repair, it was- it was- I’m sorry,
protect, fuel and then repair. And the repair is gonna be more glutathione,
and a more sulfur amino, correct? Dr. Tim Jackson: So the repairs are gonna
be more of the NT factor energy, the phospholipid complex- Dr. Justin Marchegiani: Phospholipids. Okay, and then how- Dr. Tim Jackson: Yeah. Dr. Justin Marchegiani: What does that mean
supplement wise? What supplements would you look for, and then
what foods, what good phospholipids can we eat in our diet- consume in our diet that
will help? Dr. Tim Jackson: Uh, well so, uh anything
uh, like sunflower, lecithin, as a supplement- Dr. Justin Marchegiani: Got it. Dr. Tim Jackson: -to the health but, there’s
actually a product called uh NT-factor energy- Dr. Justin Marchegiani: Mmm. Dr. Tim Jackson: Uhm, ___[19:15] helped developed
it. And uh certain, you know, chemicals and pesticides
can get lodged into the mitochondria. And according to him, uh the NT-factor energy
can take up to a year that can help displace some of these chemicals from the mitochondria. Dr. Justin Marchegiani: Very good, excellent. I love that! I mean, really good. Protect, fuel and then repair. And that makes a lot of sense. And then how are you applying this with your
patients? So if someone comes into your clinic, are
you just starting with diet and lifestyle changes first, uh what lab test are you doing,
how does this plug into your clinical model when you work with patients? Dr. Tim Jackson: Yeah, so, I mean, their-
uh, actually the U.K. has some really good mitochondrial testing because of the work
of Dr. Sarah Myhill. Uhm and I think the lab is called RED Labs. Uh, but it- you can measure various markers
here, you know- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -cerum, CoQ10- [crosstalk],
pyruvate, lactate, etc. Uh you can look at fatty acid markers on an
organic acids test- Dr. Justin Marchegiani: Yup. Dr. Tim Jackson: -if they’re high, that means
they’re not- Dr. Justin Marchegiani: [Crosstalk] Dr. Tim Jackson: Yeah. They’re not- yes, not being transported into
the into the mitochondria, you might need some L-carnitine. And the difference between L-carnitine and
acetyl carnitine – acetyl carnitine can cross the blood brain barrier. And so it can work on neurotransmitters as
well as uh mitochondrial health. Dr. Justin Marchegiani: And then carnitine’s-
like L-carnitine is more downstream, right? Dr. Tim Jackson: Yeah. Mm-hmm. Dr. Justin Marchegiani: So you would use that
to improve the carnitine shuttle and to help improve fatty acid oxidation and energy burning
from fat, right? Dr. Tim Jackson: Yeah. And then kids, on the spectrum who have low
muscle tone, uhm, you know we definitely use uh lot of carnitine, CoQ10, you know, the
gold standard in traditional uhm mitochondrial uh disorders is the muscle biopsy. But you know, traditional medicine does a
great job of finding things if aren’t there on the extreme here, or extreme here, but
most of the world exist on this continuum. And just because you’re on that continuum
doesn’t mean you don’t have it- an issue for it to be corrected. Dr. Justin Marchegiani: And we can also use
carnitine too to help modulate thyroid hormones too, I mean, if you’re on the hyper side or
on the grave’s or hyper side, carnitine is some really great modulatory effects, and
also with the lithium orotate as well. So, 2 interesting mitochondrial compounds
but also help with modulating high thyroid function. Dr. Tim Jackson: Mm-hmm- mm-hmm. Absolutely. Definitely. Dr. Justin Marchegiani: Alright, to continue
walking everyone through your kind of how you would, you know, work up a patient and
incorporate this 3-pronged approach. Dr. Tim Jackson: So basically, the more systems
that are involved in someone’s symptom presentation, the more you should take uh mitochondrial
dysfunction. And, you know, mitochondria- by making the
mitochondria work better, everything in your body will work better. Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: Now off-air we were talking
about uh, you know, the different, uh Kindle Store that I trained with an Austin Texas,
you know he calls- Dr. Justin Marchegiani: Yeah. Dr. Tim Jackson: -an mitochondrial bucket. Dr. Justin Marchegiani: Yeah. Dr. Tim Jackson: And so, let’s say you start
uh today working on healing your mitochondria, you’re not gonna notice all the benefit that
you will 6 months down the road. Uh the first system that goes offline when
the mitochondria are dysfunctional, is the nervous system. So, brain fog, fatigue, memory issues, etc. And that’s one reason why the IV NAD issues
for drug rehab because it helps kind of rehabilitate the brain and so those cravings for the drugs
and withdrawals go down dramatically. Dr. Justin Marchegiani: And what did you learn
specifically from Kindle when you were down in Austin? Dr. Tim Jackson: Uh methylation, you know,
at that time back in 2012, you know, it was all uh checking bile titers, and using uh
anti barrels, uh, and liquid boron for uhm cerebral folate deficiency, uhm, and the mitochondria
at the time he wasn’t as comprehensive uh with it, uhm but now he’s gotten more so. Dr. Justin Marchegiani: Oh, interesting. Alright, next. What else? Dr. Tim Jackson: Uhm, so, you know, outside
of the 3-pronged approach, the way, you know, that I uhm look at the mitochondria and- and
work with someone uhm with mitochondrial issues is to uh, you know, again, upregulate glutathione. Some people may not be able to tolerate glutathione
the beginning- Dr. Justin Marchegiani: And then what happens? If that is the case and they can’t even handle
sulfur amino acids like methionine or cysteine or NAC or taurine or- I don’t- m- maybe they
had little taurine but what would you do? How would you incorporate those aminos which
are tapered in, would you incorporate binders, what would you do? Dr. Tim Jackson: So, I would look at the potential
for SIBO, and the production of hydrogen sulfide gas. Uhm, I’d seen that happen a lot, uhm, you
can also- Amy Yasko has a list of, you know, foods that are really high in sulfur, uhm,
and so I would, you know, you might want go in a low sulfur diet for a period of time. Uhm, but basically, uhm using uh, like the
___[24:32]- Dr. Justin Marchegiani: Yeah molybdenum? Mm-hmm? Dr. Tim Jackson: Molybdenum, yeah. That uh will help that CBS polymorphism work
as well. Dr. Justin Marchegiani: Nice. Dr. Tim Jackson: And or facilitate that enzyme
working better. Uh, so someone can’t tolerate glutathione,
uhm, you know, we use it uh, in lower doses, uh or we’ll back off completely, open the
drainage pathways to the body, make sure the biles are moving, we’re supporting the kidneys
and liver and lymphatic system, and then out again. Dr. Justin Marchegiani: So, what does that
mean? Because obviously, I mean you need glutathione
to detoxify it- it’s a great antioxidant, right, it’s a great protector of our uhm,
our mitochondria. So, obviously we need it. So why does that mean like, do we have to
just decrease it, doesn’t that decrease our mitochondria’s ability to be protected because
it doesn’t have the histones, right? So what happens? I mean, is it- is it kind of a short-term
kind of mindset? Dr. Tim Jackson: Well, yes. it’s short term mindset for sure because you
now- you definitely need it, but in people who are really toxic, uhm their elimination
pathways are compromised, then, you know, they’re not gonna be able to tolerate it. And- Dr. Justin Marchegiani: So- so the reactions
are because we’re mobilizing too much crap? Or too much toxin essentially? Dr. Tim Jackson: Typically, yes. Dr. Justin Marchegiani: And so when you try
to upregulate like the lymph, are we giving like certain gentle herbs that may upregulate
the lymph or the detox just to kinda generally allow things to to flow better and not get
excited, do we add in binders? What does that look like? Dr. Tim Jackson: Drainage remedies- I use
drainage remedies uhm, to support the lymphatic system. You can use things like coke root- red root- Dr. Justin Marchegiani: Yeah. Dr. Tim Jackson: -uhm, but also, you know,
vibration plate, chi machines, mini rebounders to get the lymphatic system moving, dry skin
brushing, uhm drainage remedies for sure for the kidneys, liver, uhm and lymphatic system. Dr. Justin Marchegiani: Yeah. ___[26:25] is great, I’ve used it on my wife
uh before she had a- almost little bit of mastitis, breastfeeding and that works really
well, it really opens things up, I love ___[26:33], that’s great. Dr. Tim Jackson: Yeah. Dr. Justin Marchegiani: It’s very good. Yeah, so, in general, Amy Yasko has the low
sulfur diet, we’ll put the links in for the Amy Yasko diet. So we kinda keep some of the sulfur down,
we made you what some breath testing to look at hydrogen sulfide, and- and why would that
be a problem? What’s happening with that SIBO or that hydrogen
sulfide overgrowth that is affecting glutathione or making us more s- uh- sensitive to sulfur
amino acids? Dr. Tim Jackson: Well, uh, hydrogen sulfide
is a mitochondrial inhibitor. Dr. Justin Marchegiani: Aah. Dr. Tim Jackson: And, so it basically puts
the body in a state of torpor, or energy conservation. So- Dr. Justin Marchegiani: Great! Torker? Dr. Tim Jackson: Torpor. T-O-R-P-O-R. So like- Dr. Justin Marchegiani: Oh, okay. Yeah. Dr. Tim Jackson: Uh, yeah. And that was the way I was you know, described
to me but uh, you know, you can lower body temperature- Dr. Justin Marchegiani: Yeah. Dr. Tim Jackson: -decreased energy production- Dr. Justin Marchegiani: Yup. Dr. Tim Jackson: -cause major brain fog, uh,
as far as the breath testing goes, it can be helpful but 25% of the time you get a false
negative. Dr. Justin Marchegiani: So you wanna do conventional
stool- or you wanna do some more cutting stool testing to look for bacteria overgrowth? Dr. Tim Jackson: That uhm- on the organic
acids test, I think it’s 21 hydroxyphenyl acetate- Dr. Justin Marchegiani: Yeah. Dr. Tim Jackson: Uh that’s the marker that
can be indicative of SIBO, uhm you know, if you see that, uhm, and- Dr. Justin Marchegiani: Phenyl acetate is
interesting ’cause that’s also an oxidative stress marker too. Dr. Tim Jackson: Right. Right. Dr. Justin Marchegiani: Interesting. Dr. Tim Jackson: And uhm, yes, so, the uh,
SIBO. If you had concentration for any period of
time or extended period of time, the only way SIBO can develop is when there is a lack
of peristalsis or decreased peristalsis- Dr. Justin Marchegiani: Right. Dr. Tim Jackson: -so you get a migration of
the bacteria that belong in the large intestines, moving up to the small intestines which should
be relatively sterile. And so uhm, you know, err- you wanna correct
the large intestines, you wanna optimize stomach acid, uhm, bile production, digestive enzymes
and uh, you know, you can use herbs or antibiotics to treat the SIBO, but if you don’t improve
peristalsis, it’s just gonna keep coming back. Dr. Justin Marchegiani: Interesting. Now there are a lot of patients that are doing
a lot of DNA testing these days for 23 of May, what are the big DNA Markers you would
look at to say, hey there may be a mitochondrial issue, or even maybe an issue with detoxifying? What would you look at genetically, what are
the top 3 or 5 things you would look at and highlight and say, “Hey this- this may lead
you into faking there’s an issue”? Dr. Tim Jackson: So GSTM, uh, for glutathione. Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: Uhm, you know, we can measure
uh glutathione levels. Uhm, it’s best to measure the reduced- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -uhm to oxidize ratio ’cause
some people can’t recycle glutathione. Uhm, but glutathio- any polymorphisms in the
glutathione pathway, that’s gonna affect detoxification, uhm, and on mitochondria, uhm, and polymorphisms
and the superoxide dismutase pathway. Uh, that’s gonna affect it, uh, polymorphism
called endufs, uh N-D-U-F-S, uhm that affects uhm fatty acid transport- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -into mitochondria. Uhm there’s one called ACAT, A-C-A-T, and
that can affect the conversion of protein, and fats into Acetyl-CoA, and so that’s a
great limiting step in energy production. Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: And so, uhm Vitamin B1, uhm,
can be helpful in facilitating uhm or bypassing that polymorphism in particular- Dr. Justin Marchegiani: Yup. Dr. Tim Jackson: -uhm, and then there is one
called SLC, there’s a whole family of them. SLC uh 16-A1, uhm and there are others uhm
but it has- those also had to do with fatty acid transport, uhm and so, you know, that’s
where you could look at uh blood or seer models of L-carnitine. Dr. Justin Marchegiani: Would MTHFR fit into
this or COMT fit into this at all? Dr. Tim Jackson: Uh it would it in the sense
that MTHFR affects the levels of CoQ10 and carnitine- Dr. Justin Marchegiani: [Crosstalk] lower
levels so you gotta make sure those are higher? Dr. Tim Jackson: Right. Dr. Justin Marchegiani: COMT, how does that
affecting things? Dr. Tim Jackson: So COMT uhm basically uh
it affects- so it can create uh elevated uh catecholamines, and that can create a stress
response in the body, and uhm, you know, long term sympathetic dominant stress response
will turn the mitochondria. Dr. Justin Marchegiani: Can that also deplete
dopamine too? Dr. Tim Jackson: Yeah. Uhm, and so, well what it does is, people
with COMT, they don’t metabolize it as quickly depending on the exact COMT uhm, but dopamine,
norepinephrine epinephrine tend to be higher, uhm, and usually norepinephrine epinephrine
are more of an issue, uh, but yeah, it can uh for sure affect uh the mitochondria indirectly
through that mechanism. Dr. Justin Marchegiani: Great. So let’s re-summarize that, we have our COMT
and our MTHFR, right? Now you mentioned the endoxin and the B- B1
importantly, with the MTHFR you me can- you mentioned the carnitine and the CoQ10- Dr. Tim Jackson: Mm-hmm. Dr. Justin Marchegiani: With the COMT we’re
working on what decreasing sympathetic stress, breathing, not over exercising, good- good
food, is there anything you’d want or also highlight to help reduce COMT? Dr. Tim Jackson: Uh, making sure that uh you
check your estrogen levels- Dr. Justin Marchegiani: Okay. Dr. Tim Jackson: -uhm, and man, you know,
checking estradiol, and women checking- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: -E1, E2, and E3- Dr. Justin Marchegiani: Yup. Dr. Tim Jackson: Uhm, and measuring that compared
to progesterone, uhm, but that can uh, certainly affect uhm or be product of COMT. Dr. Justin Marchegiani: Great. And then the other 3 again? The first 3 that you mentioned, I wanted-
just make sure we have a good summary. Dr. Tim Jackson: So the ACAT, A-C-A-T- Dr. Justin Marchegiani: Mm-hmm. Dr. Tim Jackson: Uh, affects uhm the production
of Acetyl-CoA which is the first step in the Krebs cycle- Dr. Justin Marchegiani: Krebs cycle, yup. Dr. Tim Jackson: -and so vitamin B1, thiamine
can be used for that- Dr. Justin Marchegiani: Okay. Dr. Tim Jackson: Uhm, other polymorphisms
like ___[33:03], uh FADS, uh those affect uh an SLC, affect the transportation of fatty
acid into the mitochondria- Dr. Justin Marchegiani: Yup. Dr. Tim Jackson: And so extra carnitine may
be needed- Dr. Justin Marchegiani: Yup. Dr. Tim Jackson: Uhm and then the polymorphisms
that you know may interfere with protection of the mitochondria are GSTN or any polymorphisms
in the glutathione pathway, along with uh SOD polymorphisms- Dr. Justin Marchegiani: Very good. Dr. Tim Jackson: -and you know, to upregulate
those, uhm we can use again molecular hydrogen, we can use uhm things like ___[33:42] glutathione
or uh liposomal glutathione as well. Dr. Justin Marchegiani: If someone wants to
learn more about interpreting these genetic tests, do you have a- a resource or reference
that you like to go to? Dr. Tim Jackson: I wish I had a comprehensive
uh resource that I can tell you to go to that cover them all, uh unfortunately I don’t. Uhm I mean, there might be someone somewhere,
you know there are new apps coming out all the time, and all they’re doing you know,
it might save- this is oh, a neurotransmitter profile, this is a hormone profile, they’re
just reporting those polymorphisms that affect that particular area of the body, it’s not
a separate test. Dr. Justin Marchegiani: Got it. Is there one source you could point us to? Dr. Tim Jackson: Uhm,, I
helped them design their report, uhm I’ve done a- if you google my name Dr. Tim Jackson
I’ve done a ton of articles, interviews, podcasts, summits on methylation MTHFR, uhm so that
should be a lot of free content available if you google my name. Dr. Justin Marchegiani: Excellent. Dr. Tim if listeners wanna find more about
you and wanna work with you, what’s your website? How can they reach out? Dr. Tim Jackson: healyourbody.O-R-G, so,
or my email, I know it’s long, but it’s drtim- D-R-T-I-M-0-7-29-81, and you know- Dr. Justin Marchegiani: Oh my God, we gotta
shorten that up to like or whatever [chuckles]- Dr. Tim Jackson: I know. Dr. Justin Marchegiani: We gotta shorten that
up. Alright, we’ll put the links below so if you
don’t- if you don’t recall and don’t remember Dr. Tim’s info, we’ll put it below so it’s
a one-click option for you all. Dr. Tim, it’s been awesome. We had 2 other podcasts for Dr. Ji- Dr. Tim,
so feel free and go back and review those podcasts, great uhm treasure trove of information. Dr. Tim, thank you so much for being a part
of the podcast. And you have a phenomenal day. Dr. Tim Jackson: Thank you Dr. Justin, you
the same. Dr. Justin Marchegiani: Thanks doc!

6 thoughts on “Improving Mitochondrial Function | Podcast #222

  1. Brilliant Dr J. My new favorite vid! btw "Triphala" has been excellent at preventing the return of my SIBO by encouraging healthy peristalsis ect. I've been taking it for 6 years. It is my daily detox tonic. I buy the organic in bulk and sometimes put it into capsules or just drink triphala water or add it to matcha. Here are some details if anyone is interested. Triphala (Sanskrit: triphalā [t̪ripʰəl̪aː], “three fruits”) is an Ayurvedic herbal rasayana formula consisting of equal parts of three myrobalans, taken without seed: Amalaki (Emblica officinalis), Bibhitaki (Terminalia bellirica), and Haritaki (Terminalia chebula). Triphala is a gentle laxative that can be used daily and is not habit-forming, and has no adverse effects on the intestinal flora. The list of benefits are long. It helps to prevent: cancer, cavities, weight gain, hair loss, and is also an anti-inflammatory and offers great detoxification support, especially when doing a pathogen purge.

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