Chronic Fatigue Solutions – Podcast #147

Chronic Fatigue Solutions – Podcast #147

Dr. Justin Marchegiani: And we are live! Evan, how are we doing, man? It’s a nice little magical Monday here. Evan Brand: Magical Monday. Dr. Justin Marchegiani: [crosstalk] How are
you doing, man? Evan Brand: I feel good. I feel really good. The heat index has been like over a hundred
here. I don’t know if you watched the weather
at all but it’s like the hottest part of the country. We’re like hotter than Texas almost. It’s nuts. Dr. Justin Marchegiani: Yeah, I mean, right
now dude, I got the apple kind of weather screenshot. My wife put it on her Facebook, and it was
like– for the next week, it’s a low of a hundred to a hundred and six during the
day. So, pretty darn crazy. Very hot, so we’re inside. Actually, I’d been jumping on the water
today in like two hours. Evan Brand: Good. Dr. Justin Marchegiani: Do a little boat training
things. I’m excited about that. This weekend was good. Didn’t go on the boat this weekend, but
I look forward to go on it this week. Evan Brand: Cool. Yeah, people have a misconception about Texas
being like a desert, but Austin is– there is humidity plus that hundred degrees. That’s a scorcher. Dr. Justin Marchegiani: Yeah. That is– it’s hot for sure, but uh–
again, most of the year it’s great. That’s my kind of Texas secret. Evan Brand: That’s true. Dr. Justin Marchegiani: I got a little workout
this morning. Got up. Did some PK, you know, sprinting. Sprint some of my rower, some kettlebells,
some push-ups, some rows, some good twist ball, crunches and such. I’m feeling good. I’m ready to go. How about yourself, man? Evan Brand: Yeah. I rode the mountain bike actually this morning. I’m trying to make it a morning ritual. Typically, I’m doing some good morning sunlight
exposure as much skin as I can, and kind of gazing in the direction of the sun. But then I thought, “Why not just add exercise
on top of it.” So, I’ve been hitting the mountain bike. Probably doing just a mile or two, enough
into intense but my brain worked so much better with morning exercise, morning light. So, on the topic that we’re chatting about
today of Chronic Fatigue, that’s one of the best strategies, I believe, as some type
of morning exercise. If you’re not too fatigued, and you’re
able to do even just a walking routine or stretching, or morning Yoga, plus sunlight,
that’s like a one-two punch combo. Dr. Justin Marchegiani: Yeah, I mean, I have
a little home gym at my house so I get up and I’m trying to do a little bit of 15
minutes– 15 to 30 minutes of exercise as soon as I get up. Close to the 30 is ideal. My wife tries to just get up. She’s eight months pregnant right now, so
she just tries to get up and walk the dog for 30 minutes or so before it gets really
hot. But yeah, exercise is really important. If you look at a lot of these higher-level
CEOs, right. They talk about exercises really being a benefit
on the cognitive side, right? Help decompress stress. Helps them just feel better, less anxious,
make better decisions throughout the day. So, exercise provides some awesome components,
especially on the cognitive side. It’s very cool. Evan Brand: Yeah. the problem is when we’re talking about
the chronic fatigue, so many people they’re so tired that they can’t exercise. So, it’s really tough to give them that–
that first little bump of energy. So, maybe we’ll chat about that today, you
know. How do you actually get started with exercise
when you’ve been sedentary for so long? It could be a struggle but there are options. Dr. Justin Marchegiani: Yeah, I mean, first
things first, is find your exercise tolerance. For the most part, many people can walk at
least, right? Are they gonna at least do some walking, gentle
walking, or they can at least, you know, let’s say that’s too much, they can probably at
least do some gentle, like, Tai Chi moves, right? So that’s – there’s always a way that
you can move a little bit, right? Whether it’s walking or even uhm – on
the Tai Chi side, or even Yoga side, right? So, there’s always some level of movement
you can do. Ideally, pushing people to get onto the resistance
training side’s gonna be ideal. And even the burst training side. If you’re older and you’re not used to
that kind of compression in your joints, utilizing some kind of elliptical or rower or bike,
or something stationary, where you’re not getting the impact. But you can at least go out to all-out intensity
and then relax– all-out intensity and then relax, that’s important for the mitochondria
and for the muscles. And also, doing some resistance training is
gonna be helpful because– again, like, things like walking, they aren’t really gonna build
much muscle. I mean, you’ll burn fat, it’s good to
move, but you’re not gonna be putting on a lot of muscle on walking. So, you get that the muscle building effects,
and you get the higher growth hormone effects with the resistance training and with the
burst. So, that’s really important. Evan Brand: Now, did you cancel your gym membership? Do you still go over there now that you got
the home gym set up or do you just use the home as a compliment? Dr. Justin Marchegiani: I mean, I do both. I mean, the gym membership for me is like
19 bucks a month so it’s just nice to still have that because I can get out of the house
maybe once to twice a week just to have a different change of scenery. As you know, when you work from home, it’s
like– ah you don’t really get out much, right? Evan Brand: Right. Dr. Justin Marchegiani: Like you’re stuck,
so just an excuse to get out. But I still have the home gym, which is great. I got to start shooting some more videos from
there on some of the exercise stuff. I think that’s important. That’s kind of fun too. So, look for that coming soon. And then, what else is on your mind? I mean, let’s dive in if you’re ready. Evan Brand: Yeah, yeah, so uhm – and you
can use your wife, as your videographer for your exercise videos. People would love them on the channel, man. I don’t think you’ve done any exercise
videos yet, have you? Dr. Justin Marchegiani: No. No, I haven’t, but just simple stuff, right? Simple– you know, I kind of like the Pulse
Check mindset. Break it down into foundational movement patterns,
right. Push-pull– you know, push, pull, bend, lunge,
squat, twist, walk, sprint, right? Those were like your seven kinds of primal
movements in it. Any exercise you can think of, for the most
part, you can fit into that type of seven primal movement pattern, and then from there
you can, you know, you can have it. You can do it with weights. You can do it with cables. You can do it with TRX. You can do it with Swiss balls and body weight. And you can implement and shift according
to what you need. And also– you know, if you’re on a budget–
I mean, TRX, swiss balls, and push-up bars, maybe a couple of dumbbells, I mean, you got
like pretty much a full body facility for yourself. Evan Brand: Yeah, for probably less than 200
bucks. Dr. Justin Marchegiani: Yeah. A couple hundred bucks, man, and you got a
great gym. Evan Brand: So, let’s chat about chronic
fatigue. I mean… Dr. Justin Marchegiani: Yeah. Evan Brand: …what’s your ancestral take
on this? I mean, do you believe a chronic fatigue would
have existed in ancient times? Dr. Justin Marchegiani: Well, I think, ancient
time-wise – I mean, look at the stress, right? Stress was punctuated. It was very short term, right? It was a tiger chase, whether you live or
you die, right? It wasn’t this chronic thing where you got
a mortgage, you got all these different things you have to do to uhm– you know, to survive
so to speak. You have to get your food. You have to have your water. You know, a shelter over yourself, you kill
an animal, and then, for the most part, you’re resting, you’re relaxing all day. Well today, we have bills, mortgage, we have
ki– and then look at today, right? Kids are kind of a liability today. I mean, look how much they cost to feed, schooling,
college, where in those days, like, kids were a massive asset. Like, you want to have as many kids as possible,
so they can go hunt with you or help out around the house. I mean, it depends how far back you want to
go, right? You want to go farming days, right. My family were farmers like a hundred years
ago. So, they have… Evan Brand: Yeah. Dr. Justin Marchegiani: …you know, seven,
eight, nine, ten kids. And then, we’re all working on the farm
every day. So, they were a massive asset to the family. Today, kids are kind of a, you know, a liability,
right? Evan Brand: Yeah. I mean, you make a great point. My great grandparents – there’s old picture
– the average was like 16 kids. Dr. Justin Marchegiani: Oh, yeah. I mean, they were a massive asset. They help the family out. Today, they’re a stressor. Right? You know there’s no reason why you can’t
make your kid an asset. You know, give him some chores to do around
the house and be a team player, right? But it’s– but uhm – you know, it takes
energy and parenting to do that. So, you got to. We got to look at what we can do now to decrease
stress. Because after food needs are met, you know,
from an anthropological perspective. Food, shelter, hydration, I mean, typically
have much to worry about after that. We have a lot more we worry about in our life:
traffic, uhm – everything, right? So, looking at where we’re at now, we know
the adrenal glands play a vital role because they kind of are the interplay with our sympathetic
nervous system, so we get that spider tingling sense, right? Stress levels go high. That’s our sympathetic nervous system in
there for always in fight-or-flight, then that’s gonna really play a game on our adrenal
glands. Could look at Robert Sapolsky’s book. He’s the stress physiologist out of Stanford. It’s ‘Why Zebras Don’t Get Ulcers”? And he just talks about how animals – I
mean, it’s like, this Zebra could literally be running from a lion, right? The lion jumps on its back, like, takes on
huge chunk out of its back up but the Zebra gets away so to speak. And then you see the Zebra an hour ago–
an hour later, just grazing on some grass, like nothing happened, right? Could is this punctuated, even though half
of its– you know, back side’s gone. It’s like, “Okay. No big deal.” Like, it’s this fight-or-flight response. It’s either off or on, where we kind of
sit into this micro off-on, micro off-on all day long from work stress, from relationship
stress, and then also food stress, right? I think food stress is probably one of the
biggest stressors that keep our fight-or-flight on. Just eating a lot of refined crap and sugar
makes this blood sugar go up and down, up and down, up and down, which then puts a toll
on the adrenals. And then also, when you’re stressed, you’re
actually burning up more nutrition, right? You’re going through more B Vitamins, you’re
going through more amino acids, you’re going through more minerals, Magnesium – those
kinds of things. But then, when you’re stressed, what also
happens is you tend to crave more sugary sweet foods. So, you see this kind of vicious cycle that
happens? Stress issues, more Cortisol, more B vitamins,
more Magnesium, but also more cravings for the bad stuff, right? Alcohol, refined sugar, but then, all those
foods, they don’t contain all of the nutrients that you’re burning up at higher levels. So, you see that kind of – that little kind
of vicious cycle you get into? Evan Brand: Oh yeah. Dr. Justin Marchegiani: More stress, more
nutrient issues, but then you crave the food that actually contains none of what you need. And actually, to take those foods in, you
actually create more deficiencies. When you run those things through your glycolysis
and through your Krebs cycle, it actually takes nutrients to metabolize those things. That’s why alcoholics are so notorious for
having B Vitamin deficiencies because of the fact, it takes B vitamins to process the sugar
and alcohol. So you can actually create more deficiencies
by eating things that have zero nutrition. But you create even more than that because
you don’t get it in. But also, you have to process that sugar with
other nutrition that’s not there, right? Evan Brand: Yeah. Your gas tank’s already gone empty and you’re
trying to push the gas pedal even more. You made a great point about this because
many people when they talk about stress, they say, “I’m not stressed. I don’t feel stressed.” That’s like, when you don’t necessarily
have to feel the stress, and you might not feel the stress. This could be, all your nervous system. This is your gut. This is your pancreas you’re talking about
with the Insulin surges. This is the liver stress, where you’ve got
clogged up detox pathways. You’re not actually replenishing your Vitamin
C, which every time we look at an organics, I know I see nine out of every ten people… Dr. Justin Marchegiani: Yeah. Evan Brand: …in the organics. Their Vitamin C is completely bottomed out. And, for me, I think it’s just the afterburners. You know, in the jet fighter. You can’t use the afterburners forever. You can turn them on, but it’s not designed
for permanent use, and that’s kind of us in the modern world. And then also, the workload too. It has increased, which, you know, some people,
maybe they can’t change that, but I believe a lot of people – they’ll tell me that
they’re going on a vacation but they’ll still bring the iPad or the tablet or the
computer with them to continue working. And so, even when we’re paying for a vacation,
we’re still not letting that nervous system ever fully kind of hit the reset button. So, you get back home, and you still feel
just as stressed, if not more stressed, because you left your home environment and you just
worked the whole time. And then, obviously, there’s the deeper
issues that will get into today as well. So, I’m gonna start off, since you already
hit on the diet… Dr. Justin Marchegiani: Yeah. Evan Brand: …piece. Let’s just start off with talking about
a Vegan diet as a cause of fatigue, or specifically chronic fatigue. We’ve hit on the Vegan diet so much, and
I believe maybe, maybe, maybe you could do it right if you just tried extremely hard. You could survive. Could you ever thrive? I don’t know. I don’t know in a completely Vegan. Maybe vegetarian. We’ve hit on this. I won’t beat the drum too hard, but ideally,
if you’re getting your good animal proteins that are pasteurized, you’ve got your digestion
actually working, you’re gonna get a lot more minerals, trace nutrients. You’re gonna get your eye Iron, which are
gonna help to prevent Anemias, which is also on our list of causes of Chronic Fatigue. You know, a lot of times, Vegans are gonna
show up on their blood work with different type of Anemias. And then, when you and I run blood work for
thyroid, a lot of times we’ll see thyroid issues too. Like elevated reverse T3, which is like the
blank bullet, for people listening, “You’ve got your revolver but you’ve got some blank
bullets in there.” Because you run a Vegan diet, the body thinks
it’s starving to death. So, it says, “Well, Evan, I don’t know
when you’re gonna eat, so I might as well hold on to as much body fat as I can. This is why, so many Vegans, you’ll see
they’re actually overweight. And it’s like, “Wow. You’re living on vegetables but you’re
still overweight. What’s going on?” A lot of times, this whole cascade: the adrenals,
the thyroid, the fat storage, the malabsorption issues, all the beans and digestive problems
that they’re experiencing. This is like another vicious cycle that could
be kind of similar to the standard American diet cycle, you mentioned. Dr. Justin Marchegiani: Totally, and now,
when you look at Vegans, right? The people that do best on Vegan or vegetarian
diet, are the ones that are going to be the least Insulin-resistant. So, let me say in another way. People that are the most Insulin-sensitive,
right, their Insulin levels, their Insulin secretions are in a good place, right? Evan Brand: They do best. Dr. Justin Marchegiani: And then, they do
the best because, typically, Vegans vegetarians, they’re gonna be consuming Carbohydrates
at 300-400 grams a day, minimum. Minimum just because that’s what it takes
if you’re gonna get the protein in, and you’re combining proteins with the legumes
and rice and other things like that. You’re gonna be getting a whole bunch of
starch in so your carbohydrates will be at anywhere between 60-70 percent per day on
average if you are a Vegan. Now, also, if you try to do it the – if
you’re trying to keep the carbs down as a Vegan, then you typically, are gonna be
relying on a lot more protein powders. You’ll be doing rice protein, hemp protein,
pea protein, and you’ll probably be having to add in a lot of good fats too, like, you
know, nuts, seeds, avocado, MCT Oil, Coconut Oil, Olive Oil. So, you’ll have to really up the fats. And if you can handle the nuts and seeds,
they’ll also be really good, but you’ll also have to get a lot of the protein powders
up. And you’ll probably still need, as an insurance
policy, a sublingual B12 to ensure that you’re not getting Anemic in any way. So, that’s kind of the big thing, and if
you don’t do it that way, if you don’t do the protein powders, it’s really hard. You got to get about 300 grams of carbohydrate
as a minimum if you’re gonna do it that way. And if you have Insulin resistance, or if
you have any digestive issues, you’re gonna have to do a lot of legumes, and there’s
gonna be a lot of lectins in there and a lot of potential mineral and protein disruptors
there. That’s why, you know, Beano is such a popular
supplement to break down beans because a lot of those foods require a lot of enzymes to
break it down. It can be harder on your digestive system. Again, some people can do it. the question is, how do we differentiate why
can some people do it, and it’s– a lot of it has to do with Insulin resistance, right? The more Insulin-resistant you are, the better
you’re gonna with meat because you can get a whole bunch of proteins and fats without
the whole bunch of carbohydrates too. [crosstalk] And it’s very nutrient-dense. I mean, there’s a lot of B Vitamins in meat. If you look at the top B Vitamin foods, they’re
gonna be meats. And we just talked about B Vitamins: how important
they are for Chronic Fatigue. Fish, meats, pork, they’re gonna be really
high in B Vitamins. Also, nuts and seeds will be right behind
there too. So, that’s kind of a good take home. Evan Brand: Let’s chat about Labs for a
minute. I mean, I mentioned like, some of the thyroid
markers. Dr. Justin Marchegiani: Yeah. Evan Brand: What are you seeing on paper for
people with chronic fatigue? How would we break this down? I hit like reverse T3 about– What else is
gonna show up? Dr. Justin Marchegiani: Yeah, so when we look
at chronic fatigue, there’s three things on the hormone mitochondria side we want to
look at: we want to look at the adrenals, we want to look at thyroid, both of those
together. Right? So, making sure there’s adequate T4 to T3
conversion on the thyroids item. Making sure you’re reverse T3 levels aren’t
going too high. Number 1, looking at the adrenal side of the
fence, so making sure Cortisol’s not too high or too low. And typically, you know, the more chronic
the adrenal dysfunction is, the lower the DHEA sulfate will be as well. So making sure the adrenal components could–
also the rhythm, right? Cortisol should be having a downward slope
throughout the day. And a lot of people, they almost get kind
of reversed as the adrenal dysfunction gets worse. And the problem with that is, it tends to
significantly – it tends to significantly mess up sleep patterns, right? Evan Brand: Yeah. Dr. Justin Marchegiani: Sleep can do… Evan Brand: Let me. Dr. Justin Marchegiani: …bad health. Evan Brand: Let me restate that just so people
understand what you’re saying. So, when you’re trying to med a reverse pattern,
what we’re gonna see on your saliva test, will be low, depressed morning levels, but
then we’ll see an elevated level of Cortisol in the evening. [crosstalk] So, you’re exhausted in the
morning, but you’re also wired and tired at night. So, you can’t sleep yet you don’t feel
rested in the morning. We see that a lot, and we’ve done videos
and podcast on a specific topic, but a lot of times, it’s due to some type of stress,
like an argument at dinner, or someone’s doing blue light at night. You know, even just a tiny amount of blue
light from your phones, your tablets, etc., can crank up Cortisol. And you can fix it, with the lifestyle strategy
and there’s herbs you can use to lower evening Cortisol, like Relora. We’ve chatted about that before. Dr. Justin Marchegiani: Yeah. Evan Brand: And like the Magnolia bar, can
some of that… Dr. Justin Marchegiani: Yeah, and I’m just
doing so. My supplementation right now is doing some
adaptogenic herbs. Evan Brand: Yeah, what did you take? Dr. Justin Marchegiani: I’ve just taken
my Adrenal Revive, which has Rhodiola-Ginseng-Ashwagandha combo. And then I would just take in some amino acid
and some mitochondrial support. Just to make sure I am revved up in that maximum
potential. And, this morning, I had three hard-boiled
eggs. I had two pieces of bacon, and then I had
some coffee with butter and MCT and 15 grams of Collagen peptides. That’s kind of my day so far. And little workout actions, I’m feeling
good. So, just kind of reader in what you said,
we have the adrenals, we have the thyroid, we have the mitochondrial component, and the
mitochondria is the B Vitamins. That’s the CoQ10. That may be extra Ribose. That may be extra Carnitine. That may be some of your Krebs cycle, intermediary
compounds, like Fumarate and Malate and Succinate. So these are all really important things that
can help the adrenals that I mentioned, the thyroid and the mitochondria. So, all three of those needs to be looked
at. So, my analogy is for energy, the adrenals
are what shifts the gears. So, if you’re from first gear to second
gear, second to third, third to fourth, that’s like a standard kind of transmission, right? You shift the gears. You go up, you go fourth to fifth gear. Now you’re at highway speed, right? As you shift the gears up, that’s you generating
energy so you can deal with and meet the stress, right? That’s a faster speed. You downshift so you can relax and calm down
and control your nervous system. Those are like adaptogenic herbs. That’s like GABA. Here’s some GABA right now. I’m doing a little downshift action if you
will. So that’s upshift and downshift. That’s the adrenals. That is your body being able to meet the demands
of stress and be able to calm down from the demands of stress. That’s adrenals. Two is thyroid. That’s your resting engine tone, right? You put that car in neutral. Let’s say it’s around 700 rpm on a normal
day. Maybe on a cold day, it’s 1200 to 1400,
right, because the engine’s really cold. It’s got to generate more heat. So that resting engine tone, that’s the
thyroid. I think of the mitochondria as the gasoline
and the lubricant that’s in the car, right. It’s the engine. It’s the oil in the engine. It’s the gasoline in the tank. It’s the fluid in the car, whether it’s
wiper fluid revrols. It’s the internal fluids that help that
car to run. So, thyroid is resting engine tone, right? And we know what happens if the engine tones
too low, the car stalls out too, right? Evan Brand: Exactly. Dr. Justin Marchegiani: So, if it goes too
low, you stall out. That’s like hypothyroid, right? You’re stalling out because you’re getting
tired. You’re getting fatigue. You’re getting cold. So, let me go back. Number one is gonna be your adrenals that’s
being able to upregulate or downregulate stress. Number two is your thyroid. That’s your resting metabolism, your resting
engine tone, right. Too high, you burn up. Too low, you stall out. Number three is the fluids and the internal
fuel in the car, right? The gasoline, the oil, all the fluids to help
that car run. So, that’s kind of my analogy on the metabolic
side of energy and chronic fatigue. We ca go a little bit deeper in, next. Evan Brand: Yeah, yeah. Well– well said. I love your analogies. I think there’s been a few recent podcasts
where I’ve not heard your analogies. So I’m glad that you’re ripping those
out. Let’s chat about now, we hit on Anemias. We hit on kind of the three-body system approach
to this whole thing. Let’s talk about the other factor. We hit on blood sugar already. Let’s talk about heavy metals, Lyme disease,
Epstein-Barr. You know, some of these underlying… Dr. Justin Marchegiani: Yeah. Evan Brand: …that could be driving the adrenal-thyroid
detox problem issues. Mitochondrial [crosstalk] issues. A lot of times they go unaddressed. Now, there’s some people out there that
their whole business model’s wrapped around, like, one piece of the puzzle, like, methylation,
which is a factor, but it’s not… Dr. Justin Marchegiani: [inaudible] …your
Lyme. Evan Brand: But it’s just a factor, right? I mean, when Justin and I are working with
people, we’re never just saying, “Look. This is your one thing. There’s never one thing that broke you and
there’s not one thing that’s gonna fix you. It’s always a combination of these factors. So, if you had a diagnosis of like Epstein-Barr,
or Lyme, or mycoplasma or cytomegalovirus, or these other infections, or heavy metals. Somebody says, “Oh. You’re toxic with Mercury or Lead.” You know, yes, those issues have to be addressed,
but they’re not gonna be 95 percent of the problem. They’re gonna be a piece. Now, what percent of the pie? We don’t know, right? Because it depends on like Justin said, your
diet. What kind of diet are you following? What’s your stress load? How many hours are you working per week? How well are you sleeping? What’s your EMF exposure? What’s your exercise exposure? What’s your light environment? Are you actually getting bright sunlight in
the morning, and you’re kindling down and you’re not using artificial light in the
evening, right? All these factors will pile on top of Lyme,
heavy metals, Epstein-Barr, mono, etc., and that can make you or break you. Dr. Justin Marchegiani: Hundred percent. And of course, the diet to be there because
inflammation – one of the major factors of inflammation’s gonna be through your food,
right? So, making sure the foods dialed in. again, that’s anti-inflammatory nutrient-dense
low toxin. Our approach is gonna be kind of a Paleo Template. That’s macronutrient gnostic, so getting
the protein fat and carbs right and dialed-in for you, for your metabolism, and for what
you can actually digest. Because some people had a hard time with the
whole food component because it has – it involves digestion. And if that’s not good, we have to make
some modifications there. And that dub tails into the next component,
which is digestion, because if we have problems digesting food, that’s where all the nutrients
come into our body. So, if we can’t break that down, that’s
an issue. And not breaking down foods actually creates
a stress in the body. So, if we can’t break down the foods, then
the foods ferment, putrefy and rancidity in the gut, and create more stress and more bloating. And then, if we get really stressed and we
have a hard time evacuating our bowels or moving our bowels, right, it may get more
in the constipated side and then we start getting this auto-intoxication phenomenon
where we start reabsorbing a lot of the toxins that are in our stool. Right? That’s not good either, right? We’re literally drowning ourselves in our
own toxins. So, that component’s there. And then, we need the enzymes and Hydrochloric
acid and we know that’s important and stress affects that, right, because the more stressed
we are, the more the sympathetic nervous system decreases enzymes and decreases acids. Also, infections, right? All of these things interplay because the
more stressed we are, the more digestion’s poor. Infections can come in, and infections amplify
all of the things that we’re talking about. And infections then create more leaky gut
action, right, where the tight junctions in the Epithelium lining open up and then more
of those compounds in our gut get into our blood. And then our immune system interacts with
them more, which then creates more immune stress. And your immune system is 70-80 percent in
your gut, so the immune system always being active, it will really suck up a lot of your
energy. That’s why when you get sick and you have
like the flu or a cold, you’re really tired. You’re not tired because of the virus, you’re
tired because of the immune system allocating resources to kill the virus. So, if your immune system is always upregulated,
it will suck a lot of energy from you. Evan Brand: How about gluten, as a simple
immune stress? Dr. Justin Marchegiani: Yep. That’s why cutting gluten out can really
improve people’s energy because number one, it’s gonna create gut inflammation if you’re
gluten-sensitive, which a lot of people are. Number two, you know, unless you’re eating
the best kinds of grains, there’s still gonna be a lot of Round-up and glyphosate
and chemicals and lectins and gut irritants in there, even if the gluten component’s
not a problem. So, that may drive more leaky gut, which then
creates this more immune reactivation, upregulation, which then starts to suck energy out just
like when you get sick from a coal. Evan Brand: Yeah. Dr. Justin Marchegiani: So, that’s why cutting
those things out, really decrease your immune cell activation. Evan Brand: Well said. I want to circle back to couple things you
mentioned about malabsorption digestive problems. People may want to know how do we quantify
that? Well, you know, our philosophy’s “Always
test. Don’t guess,” So, like when we’re looking
at a stool test for someone, we can look at secretory IGA, which is kind of that first
line of defense against infections. Oftentimes, we’re gonna see that real low. In terms of stools, obviously, you can look
at your stool, if it’s floating, you know you’re not digesting your fats. So, if you’re trying to implement a Paleo
or a Ketogenic diet, and your stools are floating, we know you’re not digesting. But we can also measure it with Steatocrit,
a fecal fat marker… Dr. Justin Marchegiani: Yeah. Evan Brand: …which is important because
we can track this stuff. So, people say, “What’s the value of testing? Can I just, you know, take all these supplements
and do the diet?” You can, but eventually, you’re gonna spin
your wheels because you’ve got to have the diagnostic data to figure out what’s going
on. I had a woman last week, who her gluten antibodies
were above 400 and she told me she hadn’t eaten gluten in four years. And we know that the gluten antibodies can
be elevated for six months, but not for four years. And so, I told her, “Look. There’s got to be some exposure if you promise
me the diet’s clean. One lady I found had a chopstick she was using
every day with wheat germ oil on her chopstick. And that was causing her antibodies to go
up, but for this lady, you know, I’m thinking it’s something with her skin care products. She said she loves wearing makeup. So, I’m guessing she’s got some gluten
in her makeup somewhere. And that’s a stressor too. So, like even if you’re listening, like,
“You know what. Justin, Evan, I’ve heard you guys a million
times about the diet. I’ve already got a gluten-free diet. If you don’t test for your anti-gliadin
antibodies, you’ll never know because these people that come to us and say they’ve been
on the gluten-free diet for years, but they’ve still got issues like fatigue, boom! Now, we’ve got the Lab to prove it and we
can see why. Dr. Justin Marchegiani: Hundred percent. Hundred percent. So, again, the gut component’s really important,
and we know there are certain infections that– You know, we’re not gonna go into the treatment
because we can do a podcast in each one. Evan Brand: Yeah. Dr. Justin Marchegiani: We know things like
H. pylori, Blasto, coarse Lyme, which is Borrelia burgdorferi. We know the co-infections of Lyme, like Babesia,
Bartonella, Alexia, right? These are different things. Mycoplasma. Mycoplasma’s a big one with chronic fatigue. I think your wife had that at one point… Evan Brand: Yeah. Dr. Justin Marchegiani: …after a tick bite
too. Figure’s back. Evan Brand: We never even saw a tick. Who knows? Dr. Justin Marchegiani: Yes. Evan Brand: I’m guessing it was a tick,
but yeah. Dr. Justin Marchegiani: [inaudible]…IGA
levels for mycoplasma. They’re off the charts, so… Evan Brand: Yeah. Dr. Justin Marchegiani: I remember we treated
that and your joint pain went down and your energy came back. Evan Brand: That was scary. That was a scary time, I’ll tell you. So, infections, you know, I’ve got hands-on
experience. You know, seeing my wife struggle like that
with the infection piece, and she was definitely fatigued. A lot of times– maybe we should mention
this. I’m sorry to interrupt you, but a lot of
times with chronic fatigued there’s something else going on too, like depression, anxiety,
insomnia, sleep issues. Dr. Justin Marchegiani: Yeah. Evan Brand: It’s not just chronic fatigue
by itself. Fibromyalgia– so, usually it’s not an
isolated issue, I found. Which means that more people should be listening. Because even if fatigue doesn’t apply, there
could be other symptoms that are kind of complementary to this. Dr. Justin Marchegiani: Yeah. Fibromyalgia is intimately connected with
chronic fatigue. Why? Because your systems to regulate inflammation
are also connected to energy. So, when your ability to generate energy goes
down, your ability to resist inflammation or put the fire of inflammation out also goes
down. So then, you get very easily sore. You kind of have central allodynia kind of
thing where you’re– you know, if I were to just touch someone who has no chronic fatigue
or Fibro like, like this, it’s not a problem right? But then, their nervous system is proceeding
that as like I’m punching them at full strength, right? So, it’s just hyper upregulation of the
nervous system, and also the inability to regulate inflammation. So, the smallest things create a fire, if
they will. Evan Brand: So, it sounds like it’s everything. It’s not just a nervous system like you
mentioned, but you’re saying it will be the immune system at play here too. Dr. Justin Marchegiani: Yeah, yeah. And then you have the Myalgic Encephalomyelitis,
which is the European term for chronic fatigue, right? So, the Myalgic Encephalomyelitis is the other
one. So, we talked about the infections, right? H. pylori, Lyme, all the Lyme, co-infections… Evan Brand: Parasites. Dr. Justin Marchegiani: …parasites, Yersinia. These are gonna be big. And again, the reason why they could be so
big is because of the immune activation, number one. Number two, because of the leaky gut, which
then exacerbates the immune activation. Number three, the impaired digestion, right? The impaired digestion which means Hydrochloric
acid and enzymes drop. And then number four, it’s gonna affect
the gut bacterial balance in the gut, right? More bad bacteria than good. Evan Brand: Yeah. Dr. Justin Marchegiani: Right? Just like when there’s sharks in the water,
the sharks got all these little kinds of things sticking to its underbelly. They try to get a free ride, right? Evan Brand: Exactly. Dr. Justin Marchegiani: But when there’s
parasites there, you get those kinds of things. They try to get a free ride as well, i.e.
dysbiotic bacteria, and then, these things are gonna eat up more of your B Vitamins and
more of your nutrients. And we know that more beneficial flora actually
produces nutrition. So then, when you have that lack of beneficial
flora, then you have lack of that input of really beneficial nutrients produced by them. And then also, beneficial probiotics produce
more healthy acids that keep the environment in the gut uhm– let’s say, inhospitable
for the bad guys. Evan Brand: Yep. Yep. I’m glad you hit on the piece of them stealing
your nutrients, and also the point about the dysbiotic flora is awesome. It’s like your powerplants. If you have a bad diet, but you’ve also
got dysbiosis, I mean, I can’t think of a better combination if you wanted to create
chronic fatigue and to wipe out all the good guys. So also, you know, maybe this is worth mentioning. Antibiotics too. I mean, we’ve seen people with chronic fatigue
that it happened after a round of antibiotics to the point where some people are almost
wheelchair-bound or bed-ridden due to massive rounds of antibiotics, especially someone,
let’s say, they got a Lyme diagnosis. They start doing a bunch of antibiotics, then
their chronic fatigue due to everything going on. They’ve just destroyed themselves. Dr. Justin Marchegiani: Exactly. Hundred percent. And again, there are studies about bacterial
cidal antibiotics induce mitochondrial dysfunction, right? And I’ll pull up a study here and we’ll
go through at least the conclusion part. And we’ll put the references on below. But I have a study here on mitochondria and
antibiotics, and I have a study here on the mitochondrial dysfunction in heavy metals. Because we know heavy metals are a really
important component. We get exposed to them in our environment. It takes nutrients to detoxify from heavy
metals. So, if we have poor nutritional issues because
we’re not eating good foods or we’re not digesting those foods, then all those amino
acids and healthy sulfur-based minerals aren’t gonna be utilized for phase I and phase II
detoxification as well. Evan Brand: Yep. Well said. I’ll also add in occupational exposure of
heavy metals too. I was working last week with a female in her
70’s, a retired dentist, and I said, “What’s your exposure to mercury over your lifetime?” And she laughed and she said, “Oh, Evan,
you know, back in the 50’s,” She said, “I was putting Mercury in my hands to show
the kids all the things you can do with it.” So, who knows how toxic she is. We’ve not tested her, you know, quite yet. But, I mean, dentist? What else would be toxic occupations you would
say? I would say, anybody who’s working on a
ramp, like at an airport, people that are outside breathing in jet fuel all the time. We’ve got… Dr. Justin Marchegiani: Chemist. Potentially, Chemist, those people. I would say, the big one I think is a lot
of people that are doing a lot of lone care work. Evan Brand: Yeah. Dr. Justin Marchegiani: Their spraying a lot
of pesticides or chemicals or glyphosate, right? So, a lot of potential things and they’re
getting exposed to, and a lot of times, they aren’t going to the proper precautions regarding
exposure. They’re just uneducated about it. Evan Brand: Right. And I think we hit on this. Maybe not on this episode but as we know,
glyphosate damages mitochondria too. So, you just brought up a study about antibiotics. We know glyphosate does the same. So, if you’re not eating an organic diet,
I mean, it’s gonna be tough to get you out of this whole. What about– Let’s see. I mean it’s not too common anymore, but
people who work in like a toll booth all day, where there’s cars or a drive-through. People who work in, you know, say Starbucks. You are working at the drive-through. You’ve got these cars pumping out exhaust
fumes. They’re breathing in that stuff in all day. I think all the guys at UPS that worked out
on the ramp. You know, the meal of the night when you’ve
got these big planes, just putting out tons and tons of jet fumes. Dr. Justin Marchegiani: That’s really tough. Yeah. And I know we see a lot– I know you run
a lot of the GPL-TOX Screens and you see a lot of benzene and a lot of, basically, by-products
from gasoline metabolism, right? Evan Brand: Yeah. Yep. That and also, thanks from groundwater contamination
too. So, people that are drinking from well water
but they say, “Oh, I had it tested 20 years ago.” It’s like, well, fracking and a lot of other
industries have destroyed a lot of our groundwater, so you got to make sure that you’re filtering
your water too. If you don’t have a good clean water source,
that could be another source of your fatigue. Dr. Justin Marchegiani: Yeah, yeah. I kind of on the fence about fracking. I’ve seen some of the documentaries on them,
but I also have some family and friends that live in areas where they have to have water,
you know, uhm– basically, trucked in, right? Because the water that they have is so bad. But I’ve also heard from other people that
these people, you know, had lots of problems with their water even before fracking. So, I’m kind of the fence about that, but
anytime we’re putting toxins into the water supply and we don’t have the ability to
filter it out, that’s always really a concern, for sure. Evan Brand: Yeah, so I guess, maybe we’re
kind of all over the place, but we’re really not because we’re building a complete picture
of all these different sources. I mean, even Fluoride, for example, if you’re
drinking Fluoridated tap water, we know that that’s gonna block some of the thyroid functions. So, if you’ve got Hypothyroidism or you’ve
got autoimmune Hashimoto’s… Dr. Justin Marchegiani: Totally. Evan Brand: …I mean, that could be a source
too. So, I use a fluoride filter to remove all
that from my water. Because here in Louisville, even though the
water’s great tasting, it’s naturally filtered through our limestone, all of our
caves here, but still they add Fluoride at the very last step before they send it out
to the taps. Which hopefully, there will be a day where
that is not the case. Dr. Justin Marchegiani: Yeah, then they study
over in the UK, where they looked at certain towns or sections of areas that have Fluoridation
and certain areas that don’t. And they saw an increase in Hypothyroidism
in the areas where there was more Fluoridation. So, there’s a correlation with more Fluoride
equaling more Hypothyroidism. And that makes sense because Fluoride’s
a halide, therefore it can pinch-hit into that Iodine receptor, which is really important
for that iodination process of making thyroid hormones. What makes sense why Fluoride could affect
that iodination process, for sure. Evan Brand: Yeah. there was a Chines study too. I’m sure you saw this one, about IQ being
lower. Dr. Justin Marchegiani: Yeah. It’s like seven of ten points. I mean, this is why I’ve invested in two
filters in my house. I have a whole house filtered. That’s a carbon-based filter. And then I have one that is a reverse osmosis
filter just for the countertop. So I have one that’s whole house, which
filters about 50-75 percent of the Fluoride, and then another one that’s countertop. So, that way, the water, like I’m drinking
now, is gonna be a hundred percent clean. Now, the one of the Fluorides we have, it
actually adds back some of the good minerals, one of those filters. And they also have a trace mineral supplement
that I leave right next to the water filter. So, that could take a couple of drops of some
minerals where I have some really good sea salt I just sprinkle in. That way, I get the minerals back in too. I always tell people, like, I just– you
know, people are like, “Oh. It’s gonna take away all your minerals.” I was like, “Yeah. But what I rather have less minerals and just
add them back in or more toxins than I’m exposing myself to. Evan Brand: Exactly. Dr. Justin Marchegiani: Because I can always
just add some good minerals back in with the Trace Mineral Support that costs like five
or ten bucks… Evan Brand: Yeah. Dr. Justin Marchegiani: …versus gets exposed
to toxins over my whole life, which [inaudible], right? Evan Brand: Exactly. Yep, and – or using your good Redmond salt
or your real salt, your Celtic salts, I mean, you can replace minerals. I agree much more easily than just saying… Dr. Justin Marchegiani: [inaudible] toxins. Evan Brand: Yeah. Dr. Justin Marchegiani: Totally. Evan Brand: Glyphosate. I mean, parts per billion is bioactive so–
Dr. Justin Marchegiani: Yeah. So that’s why double filter, just to be
on the safe side. Evan Brand: I like that approach. So, when you move it won’t be too difficult. Those are pretty easy systems to install in,
who knows Dr. Justin Marchegiani: Yeah. I mean, typically, I think I had a plumber
come in for 200 bucks. He installed both of them. [crosstalk] Pretty simple. Evan Brand: Nice. Dr. Justin Marchegiani: Yup, exactly. Now I have a couple studies here I want to
kind of dive in. There’s one right here. It’s by the Journal Scientific Translational
Medicine 2013. It’s called “Bacterial Cidal Antibiotics
Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells.” Studies on mice, just so you know. It may not correlate a hundred percent but
it just gives you some good kind of ideas of why were, you know, trying to only use
antibiotics, for like, last case scenarios, but it says that– It’s in the abstract. We demonstrated these bacterial cidal antibiotics
induce effects that lead to oxidative damage to DNA, to proteins, and to the cell membranes. Mice treated with bacterial cidal antibiotics
exhibited elevated oxidative stress. Markers in the blood, oxidative tissue damage,
and upregulated expression of key genes involved in antioxidant defense mechanism, which point
to the potential physiological relevance of these antibiotic effects. Now, here’s the interesting thing. What they’re saying is more oxidative damage. What’s oxidation? Oxidation’s when you lose an electron, okay? What does that mean in real life? Cut an apple in half. Watch it start turning brown in front of you. That’s oxidation. Leave a nail out in the rain. It comes back rusty. That’s oxidation. So, what happens in your body, is you have
oxidation at the tissue and cellular level. Now that causes more antioxidants, right,
which give off an electron to help prevent that tissue from oxidizing or essentially
going bad. So, it takes a lot of nutrients out of that
reserve to prevent this oxidation from happening. Evan Brand: Wow. And now– [crosstalk] I also [inaudible]
something about the gene… Dr. Justin Marchegiani: Hold that thought,
one second. I want to just dog tail this with the last
sentence because it’s – there’s a lot of stuff here. I don’t want to lose track. Give me one last second. [breathes] Now it says, “The deleterious
effects of bactericidal antibiotics were alleviated in cell culture and of mice when they administered
antioxidants of N-acetyl-L-cysteine, which prevented the preferential bacteriostatic
antibiotic deleterious effects so by giving that extra antioxidant and sulfur amino acids. It actually neutralizes the negative effects
that happen. Sorry about that. All yours. Evan Brand: You’re good. Well, you mentioned the word genetic too. You said in that– in that abstract there
that some genes were either turned on or turned off that helped to bring on any oxidants. So that’s crazy too. You’re actually affecting things at a genetic
level with antibiotics. Dr. Justin Marchegiani: Exactly. Any other comments on that though? Evan Brand: Well… Dr. Justin Marchegiani: About the nutrients
kind of help into alleviate some of that. Evan Brand: Once I wonder is that gonna turn
on or reverse whatever happened to the gene as well. You think it will? Dr. Justin Marchegiani: Well, I mean, if we’re
talking about epigenetics, so I imagine, “Yeah it’s gonna have an epigenetic effect for
sure. Evan Brand: Cool. Dr. Justin Marchegiani: Everything we do has
a genetic effect. I mean, just sitting down and meditating for
a few minutes will have an effect on your epigenome. The question is, do you do it enough? So, that switch kind of stays on or it’s
just a temporary, you know, flicker if you will. Evan Brand: Yup, exactly. Dr. Justin Marchegiani: Now, one more study
I want to get your take on as well. Now, this is talking about heavy metals, in
particular, Mercury. When we look at heavy metals, we’re kind
of talking about Mercury, Lead, Arsenic, Cadmium, and Aluminum. Those are the big ones for the most part. But in this study, they talk about– they
talk about Mercury, and how it can accumulate in the Central Nervous System. It can impair physiological functions by disrupting
your endocrine glands. What do you think he’s talking about there? Probably thyroid, probably adrenal, probably
the HPATG-Axis. They talk about the most important mechanism
by which Mercury causes toxicity appears to be Mitochondrial damage via the depletion
of Glutathione, coupled with binding to thiol groups, which generate free radicals. Mercury has a high affinity to thiol, so that
means you’re increasing free radicals. It’s also binding up a as an– high affinity
to Selenium as well. They’re present in the amino acids. Cysteine– N-Acetylcysteine, again, we just
talked about those in the last study too, so keep that in mind. Lipoic acids, proteins, enzymes, NAC, which
are all precursors to Glutathione, which is among the most powerful intercellular antioxidants,
right? Those have bind up and prevent the loss of
electron. When you think antioxidant, think anti-electron
loss, okay? Keep on going down the list here, “which
among are the most powerful anti-cellular antioxidants available to redact against oxidative
stress and DNA peroxidation, right? That’s the– basically, the outer– in
the DNA, basically kind of uhm – coming bad if you will, right? When you have peroxidation, it’s like fats
coming bad. You heat the fats up too much, you get all
the peroxides, it goes bad. The nonsense of these methylthioninium, Glutathione,
Selenium, and fish and high omega-3 fatty acids appear strongly related to the degree
of which organic Mercury, and the protective detoxifying mechanism in human. The inclusion depletion of Glutathione, mitochondria
increase lipid peroxidation and increase oxidative damage of proteins and DNA in the brain. So, let’s break that down. What did that say? It says Mercury – increased Mercury, is
gonna cause more peroxidation, oxidation, right? That all just means damage. Think about that as damage. It’s gonna deplete a lot of those nutrients
that help make Glutathione your master antioxidant, which include your sulfur meal acids, cysteine,
glutamine, glycine, alpha lipoic acid. But it talks also about more of those nutrients,
fish oil, glutathione, cysteine, Selenium, can also help, too, though. Again, you’d probably have to do it in a
supplement form to get enough of a therapeutic level there. Evan Brand: Cool. That’s awesome. I’ve got one study too to add to this pile? Dr. Justin Marchegiani: Great. Evan Brand: It was from American Journal Clinical
Nutrition, and I’ve seen this actually on a piece of paper on Organic acid. So, I can confirm that this is accurate because
I see it time and time again. Vitamin C elevates red blood cell glutathione
levels and healthy adults. All it took, uhm– they had a course, placebo,
and then they had 500-milligram dose, daily dose, of Vitamin C, and then they had 2000
milligram daily dose Vitamin C for four to five weeks. And that was enough to elevate glutathione
levels by– let’s see. What the brains and the subjects. Some humans, they had eight percent more glutathione. Some had 84 percent more glutathione. Justin four to five weeks of supplementing
with Vitamin C. And I’ve had people taking liposomal, like glutathione or reduced glutathione,
they’re still depleted. Other organic acids, and then I’ll give
them Vitamin C, and then the glutathione goes up better. SO, I almost don’t even push people into
glutathione supplements because time and time again I see that their levels are still depleted. Like – Look, you could just supplement with
Vitamin C and replenish it just as good, if not better. And it’s gonna be significantly cheaper
in the long run too because Vitamin C is pennies on the dollar compared to glutathione. Dr. Justin Marchegiani: How much Vitamin C
are you getting? Evan Brand: I usually do about 2500 milligrams,
personally. [crosstalk] I do about a teaspoon a day. Dr. Justin Marchegiani: …of three grams
a day or so? Evan Brand: Yeah. Give or take. Dr. Justin Marchegiani: I typically only do
glutathione for people that are having more chronic G– more chronic detoxification issues. And I think doing Vitamin C, which is always
a good thing because that’s always gonna help the adrenals too. Evan Brand: Right. And it’s so cheap too. Like, liposomal glutathione. You could spend what, probably a hundred bucks
a month if you wanted to it. Dr. Justin Marchegiani: Yeah, I mean. It’s probably a little bit cheaper than
that. I know Kroshay and his liposomal – you know,
you do maybe two to four– maybe four to 8 pumps a day, so probably six years. So, yeah, it’s definitely more pricey but
it just depends, right, on what’s going on and how sick the person is. The average person probably will be better
with Vitamin C, but again more toxicity to glutathione may be something to add with the
Vitamin C. Evan Brand: Good. Good, well said. Dr. Justin Marchegiani: What are the things
you want to add, Evan? I think we hit a lot of stuff. We put some research out. Then again, that study by me that I just talked
about was the Review of Environmental Contaminants and Toxicology 2014… Evan Brand: Yeah. Dr. Justin Marchegiani: …called Mercury
Toxicity and Neuro-Degenerative Effects. We’ll put the references to these studies
in the reference section on our videos, so we’ll put it in there. You’ll see it there. Evan Brand: Good. Yeah, I just sent you the study I was talking
about too in case people want to read through. I think we hit a lot. We should probably wrap it up. I mean, we could… Dr. Justin Marchegiani: Wrap it up. Evan Brand: …we could go for hours on this
subject, and so we’ve hit on chronic fatigue but not maybe in these much details. So, uh– wrapping up, three-body system approach. It’s gonna recover so much. Adrenals, thyroid, gut, detox functions, mitochondrial. Get all those systems evaluated if you’ve
not worked with a functional medicine practitioner before, you can guess and check, sure. You can take random supplements we mentioned,
but your results will be limited. Get the testing done. Even if you just get the testing done, and
then you want to go on your own journey to figure out what it says afterwards, go for
it. But to me, the data has changed my life. I know it changed your life. It changed thousands and thousands of our
clients and patients’ lives. So, for me, I like testing. I like to see the piece of paper. I like to see the needle move. Somebody says they feel better. We looked back at organics, “Oh my God! Look. Their Krebs cycle’s actually working now.” That’s cool. Dr. Justin Marchegiani: Yeah. Evan Brand: So… Dr. Justin Marchegiani: Again, up to a hundred
percent. Is there any quick questions you wanted to
answer by the listeners or do you feel like we hit a lot of them just on our rhythm here? Evan Brand: I can pull it up. You want to read a couple off. I didn’t have… Dr. Justin Marchegiani: Yeah. Evan Brand: …the question list in front
of me. Dr. Justin Marchegiani: Yeah. So, couple things here. From Sam, do you recommend a water softener
with a reverse osmosis under the sink or a whole house filtration for home? Again, I would do both if you can, just because
of the convenience of having, you know, like– at night, before I go to bed, I’ll grab
a quick glass of water upstairs even though it’s not from my reverse osmosis. Well, it’s still really, really good. But 80-90 percent of my water’s coming from
my countertop units, so I don’t feel that bad. Plus, it’s nice having– not having to
buy shower filters for all the showers in the house. And, if you have gas they can just kind of
drink water out of their faucet upstairs. So, I like the whole house, and I like the
countertop. And, you know, really, when you factor it,
it ends up being like maybe 150 a year, 100 a year. And if you factor what you pay on bottles
of water, I mean, you’re paying that in probably every three to four months. Easy. Evan Brand: Yup. I would use the softener– [crosstalk] So
I used to live in Las Vegas. The water there is super hard. Even with the shower filter, you could see
Calcium build up. And a lot of people, you know, even my Mom,
had kidney stones from the water out there. So, for her, a water softener’s a game changer. I don’t know. I don’t know if it’s all the west coast
if it’s just Nevada, Utah, other states, but man, the water’s hard out there. Dr. Justin Marchegiani: Yeah. It would totally depend, I think, on where
your area is. So, I would uhm– more than like they’re
just talking to the company that you’re gonna go with because they probably have experienced
dealing with the whole country as a whole. So, don’t know what areas that you probably
need the water softener. And if you know, your water is very hard,
then I would invest with the water softener component. I don’t have one but, if I needed one there’s
an attachment that you can put on that would soften the water as well. Evan Brand: Perfect. Perfect. Dr. Justin Marchegiani: Yeah. And then, regarding infections, they can cause
chronic fatigue in themselves because they can create a lot of toxins that can clog up
that mitochondria. So, SIBO and infections can add to chronic
fatigue just from the toxins, like yeast and the acetaldehyde that comes off the yeast. That can slow down the mitochondria too and
create fatigue, as well. Evan Brand: Yeah. I was fatigued when I had two parasites. I was definitely fatigued, and now my energy’s
much, much better. Dr. Justin Marchegiani: Yeah. And there’s a lot of mechanisms, right? Because – Is it because it’s affecting
digestion? Is it because it’s affecting the immune
system, which is sucking up energy? Is it because of the biotoxins that are affecting
the mitochondria? So, like a lot of times, like, we don’t
know exactly, like how much is causing what? But we just know, generally, that this tends
to cause it, and here are the kind of mechanisms outline that we know which you can plug in
and interplay and have a negative effect. But we’re not gonna know exactly what percentage. But, again, in the end, it doesn’t matter
if you get better. Evan Brand: Right. No, it doesn’t. Jack, he asks, “Is AA good source for Vitamin
C?” I don’t know what he’s talking about? Do you Justin? Dr. Justin Marchegiani: Uh – AA, uh- [blows
air] Evan Brand: Ascorbic acid? I’m guessing. Dr. Justin Marchegiani: Yeah, that’s got
to be what he’s talking about. I mean, again, if you do Ascorbic acid, I
like to have some of the Bioflavonoids, the Rutin, the Hesperidin, those kinds of things
with it. Now, I like the buffered form of ascorbic
acid, as well. With like, the Ester kind of in there, and
like, some of the Potassium, Vitamin C, salts in there. So, yeah. I think it’s good but get some of the bioflavonoids
in there with it. Evan Brand: Yeah. And I– If you want the optimal, if you’re
listening to us, you want to be the top 1 percent of health, I like to mix Ascorbates,
where you can do like the Magnesium and Calcium Ascorbates mixed with Ascorbic acid. So, you’ve got kind of like, a Tri-effect
of Ascorbates. That tends to work better. Ascorbic acid is the cheapest though. So, if you’re on a budget looking to get
Vitamin C, yeah, that may cut it. Dr. Justin Marchegiani: Yeah. Yeah, I like good buffered Vitamin C as well,
but yeah, I think it’s still really good. Just try to use a really good quality, a brand
as well, GMO-free, all that’s great. And I think we kind of hit a lot of the other
questions, I mean, a lot of people have all the questions that may be off topic. I don’t want to go too far off topic. But of course, you know, if we didn’t highlight
enough diet, lifestyle, and sleep are gonna be foundational things. And if you’re not sleeping, we probably
have to fix a lot of the hormone stuff. Like the Cortisol Rhythm component that will
then help the sleep too. Evan Brand: Yep, yep. You’re welcome, Jack. Thanks for asking question. If you guys have more questions, you can always
email us. Contact Justin through his site, Contact me through my site, We always love questions and we love topic
ideas too. So, if you guys have something that we haven’t
covered that we need to, you know, we’re happy to – we’re happy to dive in. So, definitely, you could reach out to us
at any time for questions and then for consults, too. Justin’s available. And you go to his site, Book a call. We both work with people around the world,
so wherever you’re listening, it doesn’t matter. We can get lab test across the entire ocean,
to Europe, Australia, New Zealand. It doesn’t matter. And then, the good old United States, we work
with thousands of people here. So, reach out,,
and make sure to hit the thumbs up button on this video if you’re watching on YouTube. Dr. Justin Marchegiani: Yeah, if you’re
live, get it right now, guys. Give us some love. We’ll come back and we’ll do more of these
videos, so give me some hearts or some thumbs up and a couple of shares and likes. We appreciate it. It energizes us, and it makes us want to come
back, more frequently and drop more knowledge bombs. Evan Brand: Take care. Dr. Justin Marchegiani: Awesome, Evan. Have it a go, man. Evan Brand: You too. Dr. Justin Marchegiani: Bye. Evan Brand: Bye.

9 thoughts on “Chronic Fatigue Solutions – Podcast #147

  1. Thanks a lot to both of you for this wonderful podcast. I have found in it a lot of good and important information on the topic. Furthermore it was very simply spoken so I had no problem understand even if english is not my main language.

  2. Talking about exercising im 51yrs old and my rebounder trampoline or any trampoline has been AWESOME for me!

  3. whats the obsession with removing grains, and reducing whole food carbohydrates?
    These foods have a ton of health benefits and have a lot of evidence behind them

  4. Would you do an episode that's deeper on R.A. related fatigue? Also what can be done for Bronchiectasis? My lung sputum tests were all negative for the typical viruses, fungi or bacteria. Pulmonologist says they don't know why I have it.

Leave a Reply

Your email address will not be published. Required fields are marked *